C-reactive protein variations for different chronic somatic disorders
C-reactive protein variations for different chronic somatic disorders
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DOI：
10.1177/1403494809104358
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发表时间：
2009-08-01
影响因子：
3.4
通讯作者：
Ronningen, Kjersti S.
中科院分区：
文献类型：
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作者：
Haheim, Lise Lund;Nafstad, Per;Ronningen, Kjersti S.
目的：比较c反应蛋白（CRP）在一系列慢性疾病中的水平，如骨质疏松症、哮喘、糖尿病、慢性支气管炎/肺气肿、心肌梗死、当前口腔感染、中风、心绞痛、花粉热和纤维肌痛/慢性疼痛综合征。方法：总共有5323名男性参加了1972/73年和2000年奥斯陆研究的第一次和第二次健康筛查。在第二次筛查时记录的病史问卷信息被用来确定男性是否患有相关疾病。2000年收集的血清样本被储存起来，以备以后分析CRP。2000年，这些男性的年龄在48-77岁之间。结果：自我报告的心肌梗死、哮喘、糖尿病、慢性支气管炎/肺气肿、骨质疏松症或纤维肌痛/慢性疼痛综合征的男性与非病例相比，CRP平均水平显著升高。患有骨质疏松症的男性的平均值最高，为6.53，而非骨质疏松症的男性为3.55 mg/l。哮喘患者的平均CRP水平也升高，为5.01，非哮喘患者为3.47 mg/l；慢性支气管炎/肺气肿患者相应水平为4.42，非哮喘患者为3.59 mg/l。糖尿病患者分别为4.53和3.53 mg/l，心肌梗死患者分别为4.27和3.59 mg/l。纤维肌痛/慢性疼痛综合征分别为4.79 mg/l和3.60 mg/l。结论：在许多慢性疾病的老年男性中观察到CRP水平升高，表明持续的炎症反应。平均水平根据疾病而变化，并在患有特定疾病的个体中显示基线水平。当CRP用于临床感染和炎症状态时，这是有用的知识。
Aims: To compare the levels of C-reactive protein (CRP) in a range of chronic disorders such as osteoporosis, asthma, diabetes, chronic bronchitis/emphysema, myocardial infarction, current oral infections, stroke, angina pectoris, hay fever, and fibromyalgia/chronic pain syndrome. Methods: In all, 5,323 men took part in the first and second health screening of the Oslo Study in 1972/73 and 2000. Questionnaire information on medical history recorded at the second screening was used to identify men with relevant diseases. Serum samples collected in 2000 were stored for later analyses of CRP. In 2000 the men were aged 48-77 years. Results: Men with self-reported myocardial infarction, asthma, diabetes, chronic bronchitis/emphysema, osteoporosis or fibromyalgia/chronic pain syndrome had significantly elevated mean levels of CRP versus noncases. Men with osteoporosis had the highest mean values of 6.53 versus 3.55 mg/l in participants without this disease. Cases of asthma also had an increased mean CRP level of 5.01 versus 3.47 mg/l in non-cases and in chronic bronchitis/emphysema the corresponding levels were 4.42 versus 3.59 mg/l. Men with diabetes had 4.53 versus 3.53 mg/l and men with myocardial infarction had 4.27 versus 3.59 mg/l. In fibromyalgia/chronic pain syndrome the values were 4.79 mg/l and 3.60 mg/l respectively. Conclusions: Elevated CRP levels were observed in elderly men in a number of chronic diseases, indicating a persistent inflammatory response. Mean levels varied according to the disease and indicated a baseline level in the individuals with a particular disorder. This is useful knowledge when CRP is used in the clinic for infection and inflammation status.