Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors
Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors
复制标题
DOI：
10.1038/srep33961
复制
发表时间：
2016-09-27
影响因子：
4.6
通讯作者：
Garcia, Andre
中科院分区：
文献类型：
--
作者：
Dechavanne, Celia;Sadissou, Ibrahim;Garcia, Andre
据我们所知，在一项专注于获得流行地区婴儿疟疾抗体反应的研究中，从未同时探讨年龄、胎盘疟疾感染、随访期间感染、营养习惯、镰状细胞特征和个人接触按蚊叮咬的影响。对 567 名贝宁婴儿从出生到 18 个月大的期间每周进行一次随访。每 3 个月测量一次针对 5 种疟疾抗原的免疫球蛋白 G (IgG)、IgG1 和 IgG3。在单变量和多变量分析中，使用线性混合模型分析每个变量对 6 至 18 个月大婴儿获得抗疟疾抗体的影响。胎盘疟疾、营养摄入和镰状细胞特征不影响婴儿针对恶性疟原虫抗原的抗体水平。相反，年龄、出生时的疟疾抗体水平、既往和当前的疟疾感染以及接触按蚊叮咬与 6 至 18 个月大的贝宁婴儿自然获得疟疾抗体显着相关。这项研究强调了在生命早期的免疫流行病学研究或疫苗试验中需要同时考虑的不可避免的因素。
To our knowledge, effects of age, placental malaria infection, infections during follow-up, nutritional habits, sickle-cell trait and individual exposure to Anopheles bites were never explored together in a study focusing on the acquisition of malaria antibody responses among infants living in endemic areas. Five hundred and sixty-seven Beninese infants were weekly followed-up from birth to 18 months of age. Immunoglobulin G (IgG), IgG1 and IgG3 specific for 5 malaria antigens were measured every 3 months. A linear mixed model was used to analyze the effect of each variable on the acquisition of antimalarial antibodies in 6- to 18-month old infants in univariate and multivariate analyses. Placental malaria, nutrition intakes and sickle-cell trait did not influence the infant antibody levels to P. falciparum antigens. In contrary, age, malaria antibody levels at birth, previous and present malaria infections as well as exposure to Anopheles bites were significantly associated with the natural acquisition of malaria antibodies in 6- to 18-month old Beninese infants. This study highlighted inescapable factors to consider simultaneously in an immuno-epidemiological study or a vaccine trial in early life.