Methods for measuring brain morphologic features on magnetic resonance images. Validation and normal aging.
Methods for measuring brain morphologic features on magnetic resonance images. Validation and normal aging.
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DOI：
10.1001/archneur.1990.00530010035015
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发表时间：
1990
影响因子：
--
通讯作者：
Terry L. Jernigan;G. Press;J. Hesselink
中科院分区：
文献类型：
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作者：
Terry L. Jernigan;G. Press;J. Hesselink
本文描述了在磁共振图像上测量脑形态特征的方法，并提供了六个形态变量的标准数据。对于每一项测量，都给出了一个与年龄(从8岁到79岁)和平均值有关的估计函数。观察到大脑体积随年龄呈线性减小。脑室和脑沟积液的测量结果呈线性增加。发现皮质体积呈曲线减少，即使在年轻人中也是如此。在皮质和皮质下区域观察到高度非线性的高信号体积增加。所描述的方法可用于在任何测量中为每个受试者提供形态异常的年龄调整指数。它们目前正在用于对患有非局灶性脑异常和原发性情感和认知障碍的患者进行的神经行为研究。
In this article, methods for measuring brain morphologic features on magnetic resonance images are described and normative data are provided for six morphologic variables. An estimated function relating age (ranging from 8 to 79 years) to average values is given for each measure. A linear decrease over the age range is observed in the volume of the cerebrum. Linear increases are observed in measures of ventricular and sulcal fluid. A curvilinear decrease in cortical volume is found and is demonstrable even in young adults. Highly nonlinear increases in the volume of signal hyperintensities are observed in cortical and subcortical regions. The methods described may be used to provide an age-adjusted index of morphologic abnormality for each subject on any of the measures. They are currently in use in ongoing neurobehavioral studies of patients with nonfocal brain abnormalities and primary disorders of affect and cognition.