Investigation and Serologic Follow-Up of Contacts of Early Confirmed Case-Patient with COVID-19, Washington, USA
Investigation and Serologic Follow-Up of Contacts of Early Confirmed Case-Patient with COVID-19, Washington, USA
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DOI：
10.3201/eid2608.201423
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发表时间：
2020-08-01
影响因子：
11.8
通讯作者：
Biggs, Holly M.
中科院分区：
文献类型：
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作者：
Chu, Victoria T.;Freeman-Ponder, Brandi;Biggs, Holly M.
我们描述了对美国一例由严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）引起的冠状病毒病（COVID-19）早期确诊病例的接触调查。确定了病例-患者的接触者，积极监测症状，询问详细的暴露史，并通过实时逆转录PCR（rRT-PCR）和ELISA检测SARS-CoV-2感染。确定了50名接触者，对38名（76%）进行了访谈，其中11名（29%）报告与病例患者进行了无保护的面对面互动。37例（74%）呼吸道标本经rRT-PCR检测，均为阴性。其中23人（46%）在暴露后约6周采集血清样本进行ELISA检测，没有人检测到SARS-CoV-2抗体。在接受检测的接触者中，尽管与感染病例-患者发生了无保护的密切相互作用，但在本次调查中未发现二次传播。
We describe the contact investigation for an early confirmed case of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in the United States. Contacts of the case-patient were identified, actively monitored for symptoms, interviewed for a detailed exposure history, and tested for SARS-CoV-2 infection by real-time reverse transcription PCR (rRT-PCR) and ELISA. Fifty contacts were identified and 38 (76%) were interviewed, of whom 11 (29%) reported unprotected face-to-face interaction with the case-patient. Thirty-seven (74%) had respiratory specimens tested by rRT-PCR, and all tested negative. Twenty-three (46%) had ELISA performed on serum samples collected approximate to 6 weeks after exposure, and none had detectable antibodies to SARS-CoV-2. Among contacts who were tested, no secondary transmission was identified in this investigation, despite unprotected close interactions with the infectious case-patient.