The Clinicopathological Significance of the CXCR2 Ligands, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8 in Gastric Cancer
The Clinicopathological Significance of the CXCR2 Ligands, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8 in Gastric Cancer
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DOI：
10.21873/anticanres.13879
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发表时间：
2019-12-01
影响因子：
2
通讯作者：
Yashiro, Masakazu
中科院分区：
文献类型：
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作者：
Yamamoto, Yurie;Kuroda, Kenji;Yashiro, Masakazu
背景/目的：我们已报道趋化因子(C-X-C基序)受体2(CXCR2)信号与胃癌的恶性进展有关。因此，我们在GC中检测了CXCR2配体CXCL1、CXCL2、CXCL3、CXCL5、CXCL6、CXCL7和CXCL8的临床病理意义。患者和方法：采用免疫组织化学方法检测CXCR2配体在590例胃癌组织中的表达。结果：CXCL1占46.2%(257/557)，CXCL2占20.7%(122/590)，CXCL3占17.1%(101/589)，CXCL5/CXCL6占2.9%(17/589)，CXCL7占36.4%(215/590)，CXCL8占1.7%(10/585)。高侵袭深度与CXCL1的表达相关。淋巴结转移和腹膜细胞学阳性与CXCL1和CXCL7的高表达有关。CXCL1阳性患者的预后明显差于CXCL1阴性患者(P
Background/Aim: We have previously reported that chemokine (C-X-C motif) receptor 2 (CXCR2) signaling was associated with the malignant progression of gastric cancer (GC). We thus examined the clinicopathological significance of CXCR2 ligands, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8, in GC. Patients and Methods: The expression of CXCR2 ligands in 590 GC cases was investigated by immunohistochemistry. Results: The expression was as follows: CXCL1, 46.2% (257/557); CXCL2, 20.7% (122/ 590); CXCL3, 17.1% (101/589); CXCL5/ CXCL6, 2.9% (17/589); CXCL7, 36.4% (215/590); and CXCL8 1.7% (10/585) of the cases. High invasion depth was correlated with CXCL1 expression. Lymph node metastasis and peritoneal cytology positivity were correlated with high expression of CXCL1 and CXCL7. The prognoses of the CXCL1-positive patients were significantly poorer than those of the CXCL1-negative patients (p