Skin cell proliferation stimulated by microneedles.
Skin cell proliferation stimulated by microneedles.
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DOI：
10.1016/j.jccw.2012.11.001
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发表时间：
2012-03-01
期刊：
影响因子：
--
通讯作者：
Kloth, Luther C
中科院分区：
文献类型：
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作者：
Liebl, Horst;Kloth, Luther C
典型的伤口可以被定义为组织完整性的破坏。由事故或手术造成的创伤引起的伤口，通过次要意图闭合依赖于愈合的生物学阶段，即，止血、炎症、增殖和重塑（HIPR）。根据伤口的类型和严重程度，炎症阶段在受伤后立即开始，平均持续7- 14天。与炎症阶段同时或稍微延迟，细胞增殖被刺激，随后激活重塑（成熟）阶段。后一阶段可持续长达1年或更长时间，最终愈合状态由疤痕组织代表，这是一种交联的胶原蛋白形成，通常使胶原蛋白纤维沿单一方向排列。人们可能会认为，皮肤微针，涉及使用几十个或多达200个针，限制穿透1.5毫米超过1厘米（2）的皮肤将导致创伤和出血，其次是经典的HIPR。然而，情况并非如此，或者至少HIPR阶段被显著缩短，并且愈合永远不会以疤痕形成结束。相反，美容医学中用于改善皮肤质量的磨皮术是基于“消融”（破坏或伤害表层皮肤），这需要几周的愈合，包括新皮肤层的形成。这些程序引起急性炎症反应。我们认为，在皮肤的微针穿孔后发生的炎症反应不太强烈。然而，微针的作用机制似乎不同。在这里，我们审查的潜在机制，微针的皮肤促进皮肤修复后，无疤痕的治疗浅表烧伤，痤疮，色素沉着过度，和非推进周围的皮肤慢性溃疡的皮肤伤口周围的皮肤。
A classical wound may be defined as a disruption of tissue integrity. Wounds, caused by trauma from accidents or surgery, that close via secondary intention rely on the biological phases of healing, i.e., hemostasis, inflammation, proliferation, and remodeling (HIPR). Depending on the wound type and severity, the inflammation phase begins immediately after injury and may last for an average of 7-14days. Concurrent with the inflammation phase or slightly delayed, cell proliferation is stimulated followed by the activation of the remodeling (maturation) phase. The latter phase can last as long as 1year or more, and the final healed state is represented by a scar tissue, a cross-linked collagen formation that usually aligns collagen fibers in a single direction. One may assume that skin microneedling that involves the use of dozens or as many as 200 needles that limit penetration to 1.5mm over 1cm(2) of skin would cause trauma and bleeding followed by the classical HIPR. However, this is not the case or at least the HIPR phases are significantly curtailed and healing never ends in a scar formation. Conversely dermabrasion used in aesthetic medicine for improving skin quality is based on "ablation" (destruction or wounding of superficial skin layers), which requires several weeks for healing that involves formation of new skin layers. Such procedures provoke an acute inflammatory response. We believe that a less intense inflammatory response occurs following microneedle perforation of the skin. However, the mechanism of action of microneedling appears to be different. Here we review the potential mechanisms by which microneedling of the skin facilitates skin repair without scarring after the treatment of superficial burns, acne, hyperpigmentation, and the non-advancing periwound skin surrounding the chronic ulcerations of the integument.