Apomorphine and its dopamine‐like action
Apomorphine and its dopamine‐like action
复制标题
阿扑吗啡及其多巴胺样作用
DOI：
--
复制
发表时间：
1972
期刊：
影响因子：
--
通讯作者：
G. Nys
中科院分区：
文献类型：
--
作者：
R. Rekker;D. Engel;G. Nys
在水相中完全饱和。水相中的聚氧乙烯信号在苯酚含量约为5%时消失，表明POEPOP几乎不留在水相中。图2c和图d所示的相对较大的位移表明在POEPOP-苯酚-水体系中存在微孔。这进一步得到了苯酚环-质子信号(图2a和图b)的位移幅度的支持，与相应的苯酚-十六烷基大分子体系的位移相比，而在苯酚-大分子体系中，芳环基本上在水环境中，观察到非常小的位移。在水中向POEPOP中加入苯酚时，聚氧乙烯亚甲基和聚氧丙烯甲基峰显著加宽，这也表明形成了胶束；聚氧乙烯峰(但不是聚氧丙烯)也分裂了。这些胶束不一定是聚合物分子的聚集体，但可以由一个分子组成，聚氧乙烯链围绕聚氧丙烯区域滚动。这项工作得到了新南威尔士州药学会S·E·赖特研究信托基金的支持。
completely saturated in the aqueous phase. The polyoxyethylene signal from the aqueous phase disappears at about 5 % phenol, indicating that little POEPOP remains in the aqueous phase. The relatively large shifts shown in Fig 2c and d indicate the presence of mirelles in POEPOP-phenol-water systems. This is further supported by the magnitude of the shifts of the phenol ring-proton signals (Fig. 2a and b) which compares with that of the corresponding phenol-cetomacrogol systems, whereas in phenol-macrogol systems, where the aromatic rings are essentially in an aqueous environment, a very small shift is observed. Significant broadening of both polyoxyethylene methylene and the polyoxypropylene methyl peaks upon the addition of phenol to POEPOP in water is also indicative of micelle formation ; the polyoxyethylene peaks (but not polyoxypropylene) also split. These micelles need not necessarily be aggregates of polymer molecules but could consist of one molecule with the polyoxyethylene chains rolled around the polyoxypropylene region. This work was supported by the Pharmaceutical Society of New South Wales S. E. Wright Research Trust.