The Epicardium and the Development of the Atrioventricular Junction in the Murine Heart.
The Epicardium and the Development of the Atrioventricular Junction in the Murine Heart.
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DOI：
10.3390/jdb2010001
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发表时间：
2014-03-01
影响因子：
2.7
通讯作者：
Wessels A
中科院分区：
文献类型：
--
作者：
Lockhart MM;Phelps AL;van den Hoff MJ;Wessels A
在过去的十年中，对心外膜在心脏发育和再生中的作用的认识有了显著的提高。这主要是由于用于研究心外膜谱系的新的小鼠模型的可用性增加。在这里，我们集中于对心外膜和心外膜来源的细胞在房室交界处形成中的重要性的日益加深的理解。首先，通过心外膜上皮向间充质转化的过程形成心外膜下房室间充质。随后，房室外膜和心外膜衍生细胞(EPDCs)形成纤维环，这是房室心肌电分离的重要结构。最后，房室-EPDCs优先迁移到顶叶房室瓣叶，很大程度上取代了心内膜来源的细胞群。在这篇综述中，我们概述了目前已知的关于这一过程中涉及的事件的监管情况。
Insight into the role of the epicardium in cardiac development and regeneration has significantly improved over the past ten years. This is mainly due to the increasing availability of new mouse models for the study of the epicardial lineage. Here we focus on the growing understanding of the significance of the epicardium and epicardially-derived cells in the formation of the atrioventricular (AV) junction. First, through the process of epicardial epithelial-to-mesenchymal transformation (epiEMT), the subepicardial AV mesenchyme is formed. Subsequently, the AV-epicardium and epicardially-derived cells (EPDCs) form the annulus fibrosus, a structure important for the electrical separation of atrial and ventricular myocardium. Finally, the AV-EPDCs preferentially migrate into the parietal AV valve leaflets, largely replacing the endocardially-derived cell population. In this review, we provide an overview of what is currently known about the regulation of the events involved in this process.