Forced oscillation technique in veterans with preserved spirometry and chronic respiratory symptoms
Forced oscillation technique in veterans with preserved spirometry and chronic respiratory symptoms
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DOI：
10.1016/j.resp.2018.11.012
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发表时间：
2019-02-01
影响因子：
2.3
通讯作者：
Falvo, Michael J.
中科院分区：
文献类型：
--
作者：
Butzko, Ryan P.;Sotolongo, Anays M.;Falvo, Michael J.
目的：评估强制振荡技术（FOT）的实用性与保留肺功能和慢性不明原因的呼吸道symptoms.Methods：178退伍军人提到的原因不明的呼吸道症状的评估完成肺功能测试和FOT。保留肺功能测定定义为FEV 1/FVC、FEV 1和FVC >=第5百分位数。结果：71.3%的患者肺功能正常，其中124例FOT数据可接受。93/124例（75.0%）肺功能正常的退伍军人有一个或多个FOT异常结果。与FOT正常的退伍军人相比，R4-R20和/或AX异常的退伍军人的FVC、FEV 1、FEF 25 -75和弥散量（%预测值）降低（p = 0.030 top < 0.001）。结论：在我们的转诊样本中，肺功能正常的远端气道功能障碍似乎很常见，可能是需要密切监测的高危人群。
Purpose: To evaluate the utility of the forced oscillation technique (FOT) among military veterans with preserved spirometry and chronic unexplained respiratory symptoms.Methods: 178 veterans referred for evaluation of unexplained respiratory symptoms completed pulmonary function testing and FOT. Preserved spirometry was defined as FEV1/FVC, FEV1 and FVC >= 5th percentile. Frequency dependence of resistance (R4-R20) and reactance area (AX) were assessed via FOT, and R4-R20 >= 20% and AX >= 95th percentile were considered abnormal.Results: Spirometry was preserved in 71.3%, of whom 124 had acceptable FOT data. 93 of 124 (75.0%) veterans with preserved spirometry had one or more abnormal findings on FOT. Veterans with abnormal R4-R20 and/or AX had reduced FVC, FEV1, FEF25-75, and diffusing capacity (% predicted) in comparison to those with Normal FOT (p = 0.030 top < 0.001).Conclusions: In our referral sample, distal airway dysfunction in the presence of preserved spirometry appears common and may represent an at-risk group requiring closer surveillance.