Sugars including erythronic and threonic acids in human aqueous humour
Sugars including erythronic and threonic acids in human aqueous humour
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DOI：
10.1076/ceyr.19.2.131.5334
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发表时间：
1999-08-01
影响因子：
2
通讯作者：
Harvey, DJ
中科院分区：
文献类型：
--
作者：
Harding, JJ;Hassett, P;Harvey, DJ
目的.眼的水状液中的糖既作为透镜和其他前眼组织的营养源，又可能作为来自这些组织的废物的指示剂。在这项工作中，我们打算测量人类血液中的糖水平，并从白内障患者和非糖尿病的房水。初步结果后，我们决定确定一个未知的糖成分。通过hplc测量糖。未知糖峰通过气相色谱/质谱鉴定。果糖和山梨糖醇含量很少，糖尿病患者的血糖和房水中葡萄糖含量较高。在这些分析中，我们发现了一个主要成分，不对应于任何糖先前报告的水状体。这被确定为苏糖酸和羟乙磷酸的混合物。结论。糖尿病患者房水中葡萄糖水平升高，但山梨醇或果糖水平无明显升高。赤糖酸和苏糖酸是水状液和血液的正常成分。它们可以来自糖化蛋白质或来自抗坏血酸的降解。
Purpose. Sugars in the aqueous humour of the eye serve both as a source of nutrients to the lens and other anterior ocular tissues, and potentially as an indicator of waste products from these tissues. In this work we intended to measure the levels of sugars in human blood and aqueous humour from cataract patients with and without diabetes. After initial results we decided to identify an unknown sugar component.Methods. Sugars were measured by hplc. The unknown sugar peak was identified by gas chromatography/mass spectrometryResults. Very little fructose and sorbitol were found. Glucose levels were higher in both blood and aqueous from diabetic patients. During these analyses we found a major component that did not correspond to any sugar reported previously in aqueous humour. This was identified as a mixture of threonic and erythronic acids.Conclusions. Glucose levels increase in human aqueous humour in diabetes without markedly raised levels of sorbitol or fructose. Erythronic and threonic acids are normal components of aqueous humour and blood. They may be derived from glycated proteins or from degradation of ascorbic acid.