PIASy interacts with p73α and regulates cell cycle in HEK293 cells
PIASy interacts with p73α and regulates cell cycle in HEK293 cells
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DOI：
10.1016/j.cellimm.2010.04.005
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发表时间：
2010-01-01
影响因子：
4.3
通讯作者：
Yin, Zhimin
中科院分区：
文献类型：
--
作者：
Zhang, Chao;Yuan, Xia;Yin, Zhimin
p73是最近描述的转录因子p53家族的成员，经历许多翻译后修饰，诱导细胞周期停滞和凋亡。在本研究中，我们证明了PIASy，皮亚斯SUMO连接酶家族的一员，与p73 α相互作用，PIASy介导的SUMO化促进p73 α的蛋白酶体降解。PIASy过表达抑制p73 α介导的p21转录，减少G1期细胞和细胞周期折返。这些结果表明PIASy在调节p73 α转录活性中起重要作用，并且也是细胞周期机制的调节剂（C）2010 Elsevier Inc版权所有
p73, a recently described member of the p53 family of transcription factors, undergoes a number of post-translational modifications, inducing cell cycle arrest and apoptosis. In the present study, we demonstrate that PIASy, a member of the PIAS SUMO-ligase family, Interacts with p73 alpha, and that PIASy-mediated sumoylation promotes proteasomal degradation of p73 alpha. PIASy overexpression inhibits p73 alpha-mediated transcription of p21, with a reduction of cells in G1 and cell cycle reentry. These results suggest that PIASy plays an important role in regulation of p73 alpha transcriptional activity and is also a regulator of the cell cycle machinery (C) 2010 Elsevier Inc All rights reserved