Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis.
Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis.
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DOI：
10.1155/mi.2005.185
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发表时间：
2005-08-31
影响因子：
4.6
通讯作者：
Luo HS
中科院分区：
文献类型：
--
作者：
Li JH;Yu JP;Yu HG;Xu XM;Yu LL;Liu J;Luo HS
Proinflammatory mediators are important in the pathogenesis of IBD, which are regulated by activation of NF-κB. The aim of this study was to investigate whether melatonin reduces inflammatory injury and inhibits proinflammatory molecule and NF-κB in rats with colitis. Rat colitis model was established by TNBS enema. NF-κB p65, TNF-α, ICAM-1, and IκBαin colon tissue were examined by immunohistochemistry, EMSA, RT-PCR, and Western blot analysis. Expression of proinflammatory molecule and activation of NF-κB were upregulated and IκB level decreased in rats with colitis. Melatonin reduces colonic inflammatory injury through downregulating proinflammatory molecule mediated by NF-κB inhibition and blockade of IκBα degradation.
