Sperm DNA Damage and Semen Quality Impairment After Treatment With Selective Serotonin Reuptake Inhibitors Detected Using Semen Analysis and Sperm Chromatin Structure Assay (Publication with Expression of Concern)
Sperm DNA Damage and Semen Quality Impairment After Treatment With Selective Serotonin Reuptake Inhibitors Detected Using Semen Analysis and Sperm Chromatin Structure Assay (Publication with Expression of Concern)
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DOI：
10.1016/j.juro.2008.07.034
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发表时间：
2008-11-01
影响因子：
6.6
通讯作者：
Safarinejad, Mohammad Reza
中科院分区：
文献类型：
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作者：
Safarinejad, Mohammad Reza
目的：评价选择性血清素再摄取抑制剂治疗患者的精液参数和精子DNA。材料和方法：74名接受选择性血清素再摄取抑制剂治疗的有生育能力的抑郁男性（第一组）和44名健康的有生育能力的志愿者作为对照（第二组）的精液样本。所有参与者均完成了两次精液分析和体格检查。采用精子染色质结构测定法检测精子DNA断裂。结果：接受选择性血清素再摄取抑制剂治疗的患者和正常人的平均+/- SE总精子数分别为61.2 +/- 1140万和186.2 +/- 3140万（p = 0.001）。1组患者的平均运动性为48.2% +/- 4.6%，显著低于正常对照组的66.2% +/- 4.4% （p = 0.01）。精子形态正常的有14例（18.9%），对照组23例（52.3%）（p = 0.001）。接受选择性血清素再摄取抑制剂治疗的患者每次射精平均有8.1% +/- 5.4%的正常形态。选择性血清素再摄取抑制剂组与对照组相比，变性单链DNA在总细胞DNA中的含量显著增加（43.2% +/- 11.4% vs 21.4% +/- 10.6%, p = 0.01）。精液分析各项参数与治疗时间显著相关。结论：选择性血清素再摄取抑制剂可损害精液质量和精子DNA完整性。需要进一步的研究来重复我们的发现。
Purpose: Semen parameters and sperm DNA were evaluated in patients receiving selective serotonin reuptake inhibitors.Materials and Methods: Semen samples were obtained from 74 fertile, depressed men treated with selective serotonin reuptake inhibitors (group 1) and 44 healthy fertile volunteers who served as a control (group 2). Two semen analyses and physical examinations were completed in all participants. Sperm chromatin structure assay was used to detect sperm DNA fragmentation.Results: The mean +/- SE total sperm count in patients receiving selective serotonin reuptake inhibitors and in normal subjects was 61.2 +/- 11.4 million and 186.2 +/- 31.4 million, respectively (p = 0.001). Patients in group 1 had a mean motility of 48.2% +/- 4.6%, which was significantly lower than the mean of 66.2% +/- 4.4% in normal controls (p = 0.01). Normal sperm morphology was detected in 14 patients (18.9%) and 23 controls (52.3%) (p = 0.001). Patients treated with selective serotonin reuptake inhibitors had a mean of 8.1% +/- 5.4% normal forms per ejaculate. A significant increase in the amount of denatured single strand DNA in total cellular DNA was found in patients treated with selective serotonin reuptake inhibitors compared with that in controls (43.2% +/- 11.4% vs 21.4% +/- 10.6%, p = 0.01). Each semen analysis parameter significantly correlated with treatment duration.Conclusions: Selective serotonin reuptake inhibitors can impair semen quality and damage sperm DNA integrity. Further studies are needed to replicate our findings.