Pharmacologic effects approach of essential oils and their components on respiratory diseases
Pharmacologic effects approach of essential oils and their components on respiratory diseases
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DOI：
10.1016/j.jep.2022.115962
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发表时间：
2022-12-28
影响因子：
5.4
通讯作者：
Zheng，Chuan
中科院分区：
文献类型：
--
作者：
Li，Jia;Chen，Wu;Zheng，Chuan
民族药理学相关精油（EOs）是具有挥发性和独特香气的浓缩疏水液体。由芳香植物作为次生代谢物形成，EOs已被用作传统药物，在世界范围内治疗各种健康问题。历史记载表明，在中国、欧洲和许多其他地区，富含EOs的草药已被广泛用于治疗呼吸系统疾病。本文综述了芳香类植物提取物及其有效成分在临床前和临床试验中通过多靶点协同作用治疗呼吸系统疾病的传统应用和现代药理机制。材料与方法通过ScienceDirect、Web of Science、PubMed、谷歌Scholar、百度Scholar和中国知网（CNKI）等电子数据库收集EOs和呼吸系统疾病的相关信息。结果综述了EOs对慢性阻塞性肺疾病、支气管哮喘、急性肺损伤、肺部感染和肺纤维化等呼吸系统疾病的预防和治疗作用。综述了EOs治疗不同肺部疾病的分子机制，包括抗炎、抗氧化、解黏液和免疫调节机制。结论seo可作为治疗肺部疾病的补充或替代品。
Ethnopharmacological relevanceEssential oils (EOs) are concentrated hydrophobic liquids with volatility and a unique aroma. Formed by aromatic plants as secondary metabolites, EOs have been used as traditional medicines to treat various health problems worldwide. Historical records show that herbs rich in EOs have been widely used to treat respiratory diseases in China, Europe, and many other regions.Aim of the reviewThis review summarizes the traditional applications and modern pharmacological mechanisms of EOs derived from aromatic herbs and their active ingredients in respiratory diseases in preclinical and clinical trials through multitarget synergy.Materials and methodsInformation about EOs and respiratory diseases was collected from electronic databases, such as ScienceDirect, Web of Science, PubMed, Google Scholar, Baidu Scholar, and the China National Knowledge Infrastructure (CNKI).ResultsThis review presents the preventive and therapeutic effects of EOs on respiratory diseases, including chronic obstructive pulmonary disease, bronchial asthma, acute lung injury, pulmonary infection, and pulmonary fibrosis. The molecular mechanisms of EOs in treating different lung diseases are summarized, including anti-inflammation, anti-oxidation, mucolytic, and immune regulatory mechanisms.ConclusionsEOs show potential as supplements or substitutes for treating lung diseases.