VARIATIONS IN THE SERUM CONCENTRATION AND URINE EXCRETION OF ALPHA-2 HS GLYCOPROTEIN, A BONE-RELATED PROTEIN, IN NORMAL INDIVIDUALS AND IN PATIENTS WITH OSTEOGENESIS IMPERFECTA
VARIATIONS IN THE SERUM CONCENTRATION AND URINE EXCRETION OF ALPHA-2 HS GLYCOPROTEIN, A BONE-RELATED PROTEIN, IN NORMAL INDIVIDUALS AND IN PATIENTS WITH OSTEOGENESIS IMPERFECTA
复制标题
DOI：
10.1007/bf02405000
复制
发表时间：
1983-01-01
影响因子：
4.2
通讯作者：
PATERSON, CR
中科院分区：
文献类型：
--
作者：
DICKSON, IR;BAGGA, M;PATERSON, CR
在正常个体和骨生成障碍患者的血清和尿中测量α 1HS-糖蛋白的浓度。正常儿童中α 2 HS-糖蛋白的血清浓度高于成人。在女性中，数值显示出与年龄相关的逐渐下降，从21-30岁的632毫克/升下降到51-60岁的573毫克/升。在男性中没有这种与年龄相关的变化，并且值高于同龄女性。20-60岁男性的平均值为648毫克/升。在48名骨生成障碍患者中，11名患者血清中α 2 HS-糖蛋白浓度异常高;其原因尚不清楚。在24个正常个体的尿中，白蛋白：α 2 HS-糖蛋白比率的平均值为20 ± 1。血清中相应比值为70。尿中α 2 HS-糖蛋白的排泄在女童中最低（132 ± 0.01）。29 μ g/24 h）和在雄性成虫中最高（592 ±. 91 μ g/24 h）;在患有骨质疏松症的患者中的值与正常值没有差异。
The concentration of .alpha.1HS-glycoprotein was measured in the serum and urine of normal individuals and patients with osteogenesis imperfecta. The serum concentration of .alpha.2HS-glycoprotein was higher in normal children than in adults. In women values showed a progressive age-related decrease, from 632 mg/l at 21-30 yr to 573 mg/l at 51-60 yr. In men there was no such age-related variation, and values were higher than in women of comparable age. The mean value for men aged 20-60 yr was 648 mg/l. Of 48 patients with osteogenesis imperfecta, 11 had an abnormally high concentration of .alpha.2HS-glycoprotein in serum; the cause of this is not clear. In urine of 24 normal individuals the mean value of the ratio of albumin:.alpha.2HS-glycoprotein was 20 .+-. 3; in serum the corresponding ratio was 70. Urine excretion of .alpha.2HS-glycoprotein was lowest in female children (132 .+-. 29 .mu.g/24 h) and highest in male adults (592 .+-. 91 .mu.g/24 h); values in patients with ostengenesis imperfecta did not differ from normal.