Predominant site of flow limitation and mechanisms of postexertional asthma.
Predominant site of flow limitation and mechanisms of postexertional asthma.
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流量限制的主要部位和劳力后哮喘的机制。
DOI：
10.1152/jappl.1977.42.5.746
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
J. Wellman
中科院分区：
文献类型：
--
作者：
E. Mcfadden;R. Ingram;R. L. Haynes;J. Wellman
为了确定气道阻塞部位与运动诱发哮喘的机制之间是否存在关系，我们研究了12名哮喘患者在体力活动前后的最大呼气流量与空气（Vmax空气）和80%氦-20%氧（Vmax He-O2）的中肺活量比值确定的流量限制的主要部位。然后将这些观察结果与迷走神经阻滞和抑制介质释放后观察到的效应相关。5名受试者的Vmax He-O2/Vmax空气比增加，表明流量限制的主要部位位于大气道。这一组的运动后支气管痉挛取消预处理与抗胆碱能药物。7名受试者的流量比下降，表明主要是小气道阻塞。抗胆碱能药物，虽然产生支气管扩张，并没有改变他们的支气管痉挛反应的运动。然而，色甘酸二钠预处理显著降低了该组的反应。因此，哮喘患者对运动的气道反应在血流受限的主要部位是不均匀的，这一因素似乎与机制有关。
To determine if a relationship existed between the site of airway obstruction and the mechanisms of exercise-induced asthma, we studied the predominant site of flow limitation, as determined by the mid-vital capacity ratios of maximal expiratory flow with air (Vmax air) and 80% helium-20% oxygen (Vmax He-O2), before and after physical exertion in 12 asthmatics. These observations were then related to the effects seen after vagal blockade and inhibition of mediator release. Five subjects increased Vmax He-O2/Vmax air ratios suggesting that the predominant site of flow limitation was in large airways. This group had their postexercise bronchospasm abolished by pretreatment with an anticholinergic agent. Seven subjects decreased their flow ratios indicating predominant small airway obstruction. Anticholinergic agents, although producing bronchodilation, did not alter their bronchospastic response to exercise. However, pretreatment with disodium cromoglycate did significantly diminish the response of this group. Thus the airway response to exercise in asthmatics is heterogeneous in terms of predominant site of flow limitation and this factor appears to relate to mechanisms.