Effect and safety of liposome-encapsulated hemoglobin neo red cells (NRCs) as a perfusate for total cardiopulmonary bypass.
Effect and safety of liposome-encapsulated hemoglobin neo red cells (NRCs) as a perfusate for total cardiopulmonary bypass.
复制标题
脂质体封装的血红蛋白新红细胞（NRC）作为全体外循环灌注液的效果和安全性。
DOI：
10.3109/10731199509117950
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
T. Kamitani
中科院分区：
文献类型：
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作者：
A. Usuba;R. Motoki;Y. Ogata;K. Suzuki;T. Kamitani
我们开发了一种名为Neo Red Cells（NRC）的脂质体包裹的血红蛋白，NRC（1）易于循环，（2）显示出高氧转运效率，（3）具有坚固的胶囊膜。在这项研究中，我们评估了NRC作为全心肺转流（TCPB）预充液的效果。TCPB在去除57.1-73.3%的自体血液后开始，并持续7小时。在TCPB期间使用NRC时，血管阻力（VR）降至使用红细胞（RBC）时VR的1/4。这种变化表明，NRC的粘度低于RBC的粘度，从而降低了循环系统的负荷。NRC输送的氧量高于RBC输送的氧量，导致NRC的耗氧量更大。TCPB期间NRC组血清LDH水平低于RBC组。因此，我们得出结论，NRC补偿了氧转运能力的降低，这是稀释TCPB的缺点，并进一步增加了循环改善效果和抗溶血效果，这是该程序的优点。因此，它提高了稀释TCPB的安全性和有效性。
We developed a liposome encapsulated hemoglobin named Neo Red Cells (NRC), NRC (1) readily circulates, (2) shows a high oxygen transport efficiency, and (3) has a strong capsule membrane. In this study, we evaluated the effect of NRC as a priming solution for total cardiopulmonary bypass (TCPB) using a dog. The TCPB was started after removal of 57.1-73.3% of autologous blood and continued for 7 hours. During TCPB using NRC, the vascular resistance (VR) decreased to 1/4 of VR when red blood cells (RBC) were used. This change suggests that NRC, the viscosity of which is lower than that of RBC, reduced the load on the circulation system. The oxygen volume delivered by NRC was higher than that delivered by RBC, resulting in a greater oxygen consumption with NRC. During TCPB using NRC, the serum LDH level was lower than that using RBC. So we concluded that NRC compensated for the reduction in the oxygen transport ability, which is a disadvantage of dilution TCPB, and further increased the circulation improving effect and anti-hemolytic effect, which are advantages of the procedure. It, thus, enhanced both the safety and effectiveness of dilution TCPB.