Abnormal aortic fatty acid composition and small artery function in offspring of rats fed a high fat diet in pregnancy
Abnormal aortic fatty acid composition and small artery function in offspring of rats fed a high fat diet in pregnancy
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DOI：
10.1111/j.1469-7793.2001.00815.x
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发表时间：
2001-06-15
影响因子：
5.5
通讯作者：
Poston, L
中科院分区：
文献类型：
--
作者：
Ghosh, P;Bitsanis, D;Poston, L
1.子宫内环境的紊乱与成年期心血管疾病的风险增加有关。在这项研究中，我们已经确定了在妊娠期喂食高饱和脂肪饮食的大鼠的成年后代的异常血管功能是否与血脂或血管脂肪酸含量的改变有关。雌性Sprague-Dawley大鼠在妊娠前和整个妊娠期间以及断奶期间喂食育种饲料（4%脂肪）或高饱和脂肪（20%脂肪）饲料10天。然后给雌性后代喂食维持饮食（3%脂肪）直到160日龄.与饲喂繁殖饲料的母鼠的雌性后代相比，饲喂饱和脂肪饲料的母鼠的160日龄雌性后代的股动脉孤立分支中乙酰胆碱诱导的内皮依赖性舒张功能减弱。这些后代表现出血浆甘油三酯升高和血浆高密度脂蛋白胆固醇浓度降低。脂肪酸组成异常，花生四烯酸和二十二碳六烯酸含量明显降低.这项研究表明，高脂肪饮食在怀孕大鼠产生异常的血管功能，血脂紊乱和改变血管脂肪酸含量在其雌性后代在成年期。
1. Disturbances of the in utero environment are associated with an increased risk of cardiovascular disease in adulthood. In this study we have determined whether abnormal vascular function in the adult offspring of rats fed a high saturated fat diet in pregnancy is associated with altered plasma lipids or vascular fatty acid content.2. Female Sprague-Dawley rats were fed a breeding diet (4 % fat) or a diet high in saturated fat (20 % fat) for 10 days prior to and throughout pregnancy, and during weaning. Female offspring were then fed a maintenance diet (3 % fat) until 160 days of age.3. Endothelium-dependent relaxation induced by acetylcholine was blunted in isolated branches of the femoral artery from 160-day-old female offspring of dams fed the saturated fat diet when compared with female offspring of dams fed the breeding diet. These offspring exhibited elevated plasma triglyceride and reduced plasma high density lipoprotein cholesterol concentrations.4. The fatty acid composition of the aortas was abnormal, with a marked reduction in the content of arachidonic and docosahexaenoic acids.5. This study demonstrates that a high fat diet in pregnant rats produces abnormal vascular function, plasma lipid disturbances and altered vascular fatty acid content in their female offspring during adulthood.