Interaction of host cellular proteins with components of the hepatitis delta virus.
Interaction of host cellular proteins with components of the hepatitis delta virus.
复制标题
宿主细胞蛋白与乙型肝炎病毒成分的相互作用。
DOI：
10.3390/v2010189
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Pelchat M
中科院分区：
文献类型：
--
作者：
Greco-Stewart V;Pelchat M
The hepatitis delta virus (HDV) is the smallest known RNA pathogen capable of propagation in the human host and causes substantial global morbidity and mortality. Due to its small size and limited protein coding capacity, HDV is exquisitely reliant upon host cellular proteins to facilitate its transcription and replication. Remarkably, HDV does not encode an RNA-dependent RNA polymerase which is traditionally required to catalyze RNA-templated RNA synthesis. Furthermore, HDV lacks enzymes responsible for post-transcriptional and -translational modification, processes which are integral to the HDV life cycle. This review summarizes the known HDV-interacting proteins and discusses their significance in HDV biology.
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