Vascular Endothelial Growth Factors and Angiopoietins in Presentations and Prognosis of Papillary Thyroid Carcinoma
Vascular Endothelial Growth Factors and Angiopoietins in Presentations and Prognosis of Papillary Thyroid Carcinoma
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DOI：
10.1002/jso.21844
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发表时间：
2011-04-01
影响因子：
2.5
通讯作者：
Yeh, Chi-Ju
中科院分区：
文献类型：
--
作者：
Hsueh, Chuen;Lin, Jen-Der;Yeh, Chi-Ju
目的：甲状腺癌细胞血管生成在术后持续性、复发性和转移性乳头状甲状腺癌(PTC)中起重要作用。本研究旨在探讨血管生成素-1(Ang-1)、血管生成素-2(Ang-2)、Tek/Tie-2受体和血管内皮生长因子(VEGF)在正常甲状腺组织、良性甲状腺组织和不同分期PTC中的表达。我们认为血管生成因素在甲状腺癌局部区域颈部或远处转移的表现中是重要的。材料和结果：共有101例甲状腺切除受试者的组织被纳入研究。收集22例正常对照和79例不同TNM分期的甲状腺癌患者。Ang-1在转移组的平均免疫染色分数最高。与正常甲状腺组织和良性甲状腺组织相比，甲状腺癌组织中三种血管生成因子和Tie-2受体的表达均显著升高。在PTC中，三种血管生成因子和Tie-2受体在复发病例中显著高表达。结论：免疫组织化学染色显示VEGF、Ang-1、Ang-2在PTC组织中的表达与临床分期有关，但这些因素的长期随访结果尚需进一步了解。J.Surg.Oncol2011；103：395-399。(C)2010年Wiley-Liss公司
Aims: Angiogenesis from thyroid cancer cell plays the important roles in post-surgical persistent, recurrent, and metastatic papillary thyroid cancer (PTC). This study is to investigate the expression of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), Tek/Tie-2 receptor, and vascular endothelial growth factors (VEGF) in normal, benign thyroid tissues and different stage of PTC. We expect angiogenetic factors are important in the presentation of local-regional neck or distant metastases in PTC.Materials and Results: A total of 101 tissues from the subjects underwent thyroidectomy were enrolled in the study. There were 22 control and 79 thyroid cancer patients in different TNM stagings were collected. Ang-1 illustrated highest mean immunostaining score in metastatic group. Comparing with normal and benign thyroid tissues, thyroid cancer tissues illustrated significantly high expression of three angiogenetic factors and Tie-2 receptor. Of the PTC, significantly high expression of three angiogenetic factors and Tie-2 receptor were illustrated in recurrent cases. VEGF showed statistical difference in disease-free cancer mortality, and recurrent groups.Conclusions: Immunochemical staining illustrated VEGF, Ang-1, Ang-2 expression in PTC tissues related to clinical staging; however, we need more information concerning these factors with long-term follow-up results. J. Surg. Oncol 2011; 103: 395-399. (C) 2010 Wiley-Liss, Inc.