Effects of prepregnancy body mass index and weight gain during pregnancy on perinatal outcome in glucose-tolerant women
Effects of prepregnancy body mass index and weight gain during pregnancy on perinatal outcome in glucose-tolerant women
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DOI：
10.1016/j.diabet.2011.07.005
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发表时间：
2012-02-01
影响因子：
7.2
通讯作者：
Corrado, F.
中科院分区：
文献类型：
--
作者：
Di Benedetto, A.;D'anna, R.;Corrado, F.
目的。 - 本研究的目的是确定母亲孕前体重指数 (BMI) 和孕期体重增加对非糖尿病女性围产期结局的影响。方法。 - 对2004年1月至2009年12月期间在我们大学医院接受葡萄糖激发试验（GCT）并随后分娩的连续女性的临床记录进行回顾性审查。孕前BMI和孕期体重增加根据美国医学研究所指南（1990）进行分类。结果。 - 在符合条件的 2225 名患者中，与正常体重女性 (4.5%) 相比，肥胖和超重女性的巨大婴儿比例更高 (分别为 17.7% 和 8.9%)。然而，如果按照孕期体重增加来考虑，则只有肥胖组（OR：8.3，95% CI：2.4-28.4）和超重组（OR：2.9，95% CI：1.2-6.8）体重增加过多的结果具有统计学意义。此外，肥胖女性的手术分娩率明显高于正常体重女性（分别为 56% 和 36%），尽管在本例中，妊娠期间正常体重增加和体重过度增加没有差异（OR：1.4，95% CI：0.7-2.6）。结论。 - 超重和肥胖女性患巨大儿的风险较高，但怀孕期间控制好体重可以限制巨大儿的风险。与正常体重组相比，肥胖组的手术分娩率也明显更高，但这与怀孕期间体重过度增加无关。 (C) 2011 Elsevier Masson SAS。版权所有。
Aim. - The aim of this study was to determine the effects of maternal prepregnancy body mass index (BMI) and weight gain during pregnancy on perinatal outcome in non-diabetic women.Methods. - The clinical records of consecutive women who had undergone a glucose challenge test (GCT) and then delivered in our university hospital between January 2004 and December 2009 were retrospectively reviewed. Prepregnancy BMI and pregnancy weight gain were classified according to the US Institute of Medicine guidelines (1990).Results. - Of the eligible 2225 patients, obese and overweight women had a greater percentage of macrosomic babies (17.7% and 8.9%, respectively) compared with normal weight women (4.5%). However, when considered according to weight gain during pregnancy, the results were statistically significant only for excess weight gain in the obese (OR: 8.3, 95% CI: 2.4-28.4) and overweight (OR: 2.9, 95% CI: 1.2-6.8) groups. Also, the surgical delivery rate was significantly higher in the obese vs normal weight women (56% vs 36%, respectively) although, in this case, there was no difference according to normal and excess weight gain during pregnancy (OR: 1.4, 95% CI: 0.7-2.6).Conclusion. - Overweight and obese women have an increased risk rate of macrosomia that can be limited by well-controlled weight gain during pregnancy. There was also a significantly higher rate of surgical delivery in the obese compared with the normal weight group that was, however, independent of excessive weight gain during pregnancy. (C) 2011 Elsevier Masson SAS. All rights reserved.