Laser-induced thermotherapy -: Intra- and extralesionary recurrence after incomplete destruction of experimental liver metastasis
Laser-induced thermotherapy -: Intra- and extralesionary recurrence after incomplete destruction of experimental liver metastasis
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DOI：
10.1007/s00464-001-0006-6
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发表时间：
2001-11-01
影响因子：
3.1
通讯作者：
Germer, CT
中科院分区：
文献类型：
--
作者：
Isbert, C;Roggan, A;Germer, CT
目的：本研究的目的是确定能量（J/mm（3）的肿瘤体积）和温度所需的实验性肝肿瘤的激光诱导热疗（LITT），并找出局部复发的原因和领域，随后不完全treatment.Methods：在VX-2荷瘤兔LITT进行使用钕：钇铝石榴石（Nd：YAG）激光（1064 nm）与扩散尖端喷头和温度反馈系统。将动物随机分为四组（n=20），肿瘤边缘的目标温度不同，如下：45 ℃，50 ℃，55 ℃和60 ℃。将目标温度保持恒定10分钟。在LITT后0 h、24 h、96 h和14 d进行组织学检查（苏木精-伊红[H&E]、烟酰胺腺嘌呤二核苷酸磷酸[NADPH]-脱氢酶）。结果：治疗前肿瘤体积为2191 +/- 61 mm（3），所有组均相同（p>0.05）。达到目标温度的能量和所需的总能量、病灶大小和不完全肿瘤消融（复发）率如下所示（（a）p
Purpose: The aim of this study was to determine the energy (J/mm(3) tumor volume) and temperature required for a complete laser-induced thermotherapy (LITT) of experimental liver tumors, and to find out causes and areas of local recurrence followed by incomplete treatment.Methods: In VX-2 tumor-bearing rabbits LITT was performed using neodymium:yttrium-aluminum-garnet (Nd:YAG) laser (1064 nm) with a diffuser-tip applicator and a temperature feedback system. The animals were randomized into four groups (n=20) that differed in the target temperature at the tumor border as follows: 45 degreesC, 50 degreesC, 55 degreesC and 60 degreesC. The target temperature was held for 10 min constant. Histologic examination (hematoxylin and eosin [H&E], nicotinamide adenine dinucleotide phosphate [NADPH]-dehydrogenase) was performed at 0 h, 24 h, 96 h, and 14 days aver LITT.Results: The pretreatment tumor volume of 2191 +/- 61 mm(3) was the same for all groups (p>0.05). Energy up to target temperature and total energy required, lesion size, and the rate of incomplete tumor ablation (recurrences) are listed below ((a)p