The role of CA1 in the acquisition of an object-trace-odor paired associate task
The role of CA1 in the acquisition of an object-trace-odor paired associate task
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DOI：
10.1037/0735-7044.119.3.781
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发表时间：
2005-06-01
影响因子：
1.9
通讯作者：
Gilbert, PE
中科院分区：
文献类型：
--
作者：
Kesner, RP;Hunsaker, MR;Gilbert, PE
本实验旨在确定是否添加一个时间组件的对象气味关联任务将招募海马。在学习物体-痕量-气味任务之前，大鼠被给予CA 1、CA 3或对照损伤。向大鼠呈现物体10秒，之后移除物体，接着是10秒的跟踪期，接着呈现50厘米远的气味。如果气味和物体配对，老鼠就在气味杯里挖东西作为奖励。如果受损，大鼠将避免挖掘。有CA 1病变的大鼠无法建立这种关联，而有CA 3病变的大鼠表现与对照组一样。这些结果支持了海马参与形成任意联想的观点，这些联想不一定涉及空间，只要它们涉及时间成分。
This experiment was designed to determine whether adding a temporal component to an object-odor association task would recruit the hippocampus. The rats were given CA1, CA3, or control lesions prior to learning the object-trace- odor task. Rats were presented with an object for 10 s, after which the object was removed, followed by a 10-s trace period, followed by the presentation of an odor 50 cm away. If the odor and the object were paired, rats were to dig in the odor cup for a reward. If Impaired, rats were to refrain from digging. Rats that had CA1 lesions were unable to make the association, whereas rats that had CA3 lesions performed as well as controls. These results support the idea that the hippocampus is involved in forming arbitrary associations that do not necessarily involve space as long as they involve a temporal component.