Response to LPS in female offspring from sows treated with cortisol during pregnancy
Response to LPS in female offspring from sows treated with cortisol during pregnancy
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DOI：
10.1016/j.physbeh.2006.11.013
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发表时间：
2007-03-16
影响因子：
2.9
通讯作者：
Taverne, Marcel
中科院分区：
文献类型：
--
作者：
de Groot, Johanna;Kranendonk, Godelieve;Taverne, Marcel
产前应激已被证明是程序的反应性下丘脑-垂体-肾上腺轴（hpa -轴）和后代的行为。在养猪业中，母猪在妊娠期间暴露在紧张的条件下。以前，怀孕母猪的皮质醇治疗已被证明可以改变仔猪的应激反应和免疫参数。在目前的研究中，我们探讨了怀孕母猪的皮质醇治疗是否会影响后代对炎症刺激的反应。母猪在妊娠第一、第二或第三期口服皮质醇，或在此期间服用安慰剂。8周龄时，雌性后代静脉注射脂多糖（LPS）。在妊娠第一和第三期接受皮质醇的母猪的后代对LPS表现出更高的发热反应。妊娠期母猪的皮质醇处理不影响后代对LPS的皮质醇反应。lps诱导的疾病行为，在人类接近试验中被测量为潜伏期，在妊娠第二阶段接受皮质醇治疗的母猪的后代中，似乎恢复得更快。这些结果表明，产前皮质醇暴露可提高母仔猪对炎症刺激的反应性。(c) 2006爱思唯尔公司版权所有。
Prenatal stress has been shown to program responsiveness of the hypothalamus-pituitary-adrenal axis (HPA-axis) and behavior in offspring. In pig husbandry, sows are exposed to stressful conditions during gestation. Previously, cortisol treatment of pregnant sows has been shown to alter stress responsiveness and immunological parameters in their piglets. In the present study, we explored whether cortisol treatment of pregnant sows affects the offspring's response to an inflammatory stimulus. Sows were treated orally with cortisol either during the first, second, or third period of gestation, or received a placebo during this period. At 8 weeks of age, female offspring were injected intravenously with lipopolysaccharide (LPS). Offspring of sows that received cortisol during the first and third period of gestation showed a higher fever response to LPS. Cortisol treatment of sows during gestation did not affect offspring's response to LPS with regard to their cortisol response. LPS-induced sickness behavior, which was measured as the latency time in a human approach test, appeared to recover more quickly in offspring from sows that received cortisol during the second period of gestation. These results suggest that prenatal cortisol exposure programs responsiveness to inflammatory stimuli in female piglets. (c) 2006 Elsevier Inc. All rights reserved.