WORKING MEMORY IN AGED RATS
WORKING MEMORY IN AGED RATS
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DOI：
10.1037/0735-7044.103.5.975
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发表时间：
1989-10-01
影响因子：
1.9
通讯作者：
CANDY, JM
中科院分区：
文献类型：
--
作者：
AGGLETON, JP;BLINDT, HS;CANDY, JM
在空间（空间延迟不匹配样本）和非空间（对象延迟不匹配样本）的工作记忆测试中，比较了年轻大鼠和老年大鼠的表现。尽管有证据表明，年龄增长会减缓这两项任务的习得，但一旦掌握了任务，在长达60秒的不同记忆间隔内的表现都是正常的。然而，当每次测试中要记住的位置数量从一个增加到两个时，在空间测试中的表现就会受到损害。本研究的结论是，在某些条件下，老年大鼠的保留能力可能不会改变，一些习得障碍并不反映学习或记忆本身的改变，但是，与其他研究一样，可能会发现空间位置记忆的缺陷。
The performances of young and aged rats were compared on a spatial (spatial delayed non-matching-to-sample) and a nonspatial (object delayed nonmatching-to-sample) test of working memory. Although evidence was found that aging slowed acquisition of both of these tasks, performance over different retention intervals of up to 60 s was normal once the task was mastered. An impairment was found, however, in the performance of the spatial test when the number of locations to be remembered on each trial was increased from one to two. The conclusions of this study are that under some conditions, the retention capabilities of aged rats may not change and that some acquisition impairments do not reflect alterations in learning or memory per se, but, in common with other studies, deficits in the remembrance of spatial locations may be found.