Arsenic Exposure Decreases Adiposity During High-Fat Feeding
Arsenic Exposure Decreases Adiposity During High-Fat Feeding
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DOI：
10.1002/oby.22770
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发表时间：
2020-03-20
期刊：
影响因子：
6.9
通讯作者：
Sargis, Robert M.
中科院分区：
文献类型：
--
作者：
Carmean, Christopher M.;Kirkley, Andrew G.;Sargis, Robert M.
目的 砷是一种内分泌干扰化学物质，与糖尿病风险相关。肥胖增加是糖尿病及其合并症的一个重要危险因素。在此，在小鼠中评估了慢性砷暴露对肥胖和代谢健康的影响。方法给雄性C57BL/6J小鼠随意提供正常或高脂肪饮食和水+/-50mg/L亚砷酸钠。测量体重、身体成分、胰岛素敏感性、能量消耗和运动活动的变化。将肥胖测量值与肝脏中积累的砷进行比较。结果尽管砷暴露均匀，但砷暴露小鼠体内砷水平存在显着差异。暴露小鼠的肝脏砷水平与总体体重增加、个体脂肪库质量和肝脏甘油三酯积累呈负相关。在正常饮食的小鼠中没有观察到任何影响。对于高脂肪饮食的小鼠，砷暴露降低了空腹胰岛素水平、胰岛素抵抗和β细胞功能的稳态模型评估以及全身胰岛素抵抗。砷暴露不会改变能量消耗或活动。结论总的来说，这些数据表明砷具有抗肥胖作用，并且源头浓度很难预测砷积累和表型结果。在未来的研究中，研究人员在评估砷暴露的结果时应考虑砷的内部积累，而不是源浓度。
Objective Arsenic is an endocrine-disrupting chemical associated with diabetes risk. Increased adiposity is a significant risk factor for diabetes and its comorbidities. Here, the impact of chronic arsenic exposure on adiposity and metabolic health was assessed in mice.Methods Male C57BL/6J mice were provided ad libitum access to a normal or high-fat diet and water +/- 50 mg/L of sodium arsenite. Changes in body weight, body composition, insulin sensitivity, energy expenditure, and locomotor activity were measured. Measures of adiposity were compared with accumulated arsenic in the liver.Results Despite uniform arsenic exposure, internal arsenic levels varied significantly among arsenic-exposed mice. Hepatic arsenic levels in exposed mice negatively correlated with overall weight gain, individual adipose depot masses, and hepatic triglyceride accumulation. No effects were observed in mice on a normal diet. For mice on a high-fat diet, arsenic exposure reduced fasting insulin levels, homeostatic model assessment of insulin resistance and beta-cell function, and systemic insulin resistance. Arsenic exposure did not alter energy expenditure or activity.Conclusions Collectively, these data indicate that arsenic is antiobesogenic and that concentration at the source poorly predicts arsenic accumulation and phenotypic outcomes. In future studies, investigators should consider internal accumulation of arsenic rather than source concentration when assessing the outcomes of arsenic exposure.