Electrolyte solution approximating plasma concentrations with increased potassium for routine fluid and electrolyte replacement.
Electrolyte solution approximating plasma concentrations with increased potassium for routine fluid and electrolyte replacement.
复制标题
电解质溶液接近血浆浓度，并增加钾含量，用于常规液体和电解质补充。
DOI：
10.1001/jama.1952.02930100045010
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发表时间：
1952
影响因子：
--
通讯作者：
J. Lattimer
中科院分区：
文献类型：
--
作者：
C. L. Fox;J. M. Winfield;L. Slobody;C. M. Swindler;J. Lattimer
最近的研究强调了维持血浆和组织细胞中电解质和水的正常水平的必要性。这是难以实现的，因为通常可用于胃肠外治疗的主要置换液的电解质组成与正常血浆显著不同。例如，0.9%的氯化钠溶液含有过多的氯化物，但没有碳酸氢盐和钾。因此，试图设计一种血浆电解质的水溶液来纠正大多数异常。通过动物实验获得初步近似解，并进行临床试验。迄今为止的结果令人鼓舞，足以证明我们的观察报告是正确的。首先研究出血是因为它在医学和外科中的普遍性和重要性以及它在狗中的可重复性。从未麻醉的狗中取出大量血液，同时用电解质溶液置换。1在此期间和之后
Recent studies have emphasized the desirability of maintaining normal levels of electrolytes and water in plasma and tissue cells. This is difficult to accomplish because the electrolyte composition of the primary replacement solutions generally available for parenteral therapy is significantly different from normal plasma. For example, 0.9% sodium chloride solution contains too much chloride but no bicarbonate and no potassium. Attempts were made, therefore, to devise a water solution of plasma electrolytes to correct most anomalies. Animal experiments were conducted to obtain the first approximations, and then the proposed solution was subjected to clinical trial. The results to date have been sufficiently encouraging to warrant this report of our observations. ANIMAL EXPERIMENTS Hemorrhage was investigated first because of its ubiquity and importance in medicine and surgery and its reproducibility in dogs. Massive volumes of blood were removed from unanesthetized dogs and concurrently replaced with an electrolyte solution. 1 During and after the