c-Myb is essential for early T cell development
c-Myb is essential for early T cell development
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DOI：
10.1101/gad.13.9.1073
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发表时间：
1999-05-01
影响因子：
10.5
通讯作者：
Siu, G
中科院分区：
文献类型：
--
作者：
Allen, RD;Bender, TP;Siu, G
c-Myb转录因子对于胎儿造血是重要的，并且已经提出介导淋巴细胞发育的后期阶段。使用纯合无效c-Myb/Rag 1嵌合小鼠，我们已经确定，c-Myb在巨噬细胞和淋巴细胞从前体干细胞分化中起着重要作用。我们还确定，c-Myb的删除导致一个完全的块在早期T细胞发育之前的寡能胸腺细胞成熟为永久性T细胞前体。这些数据表明，c-Myb在造血的多个阶段起着重要作用，并且在T细胞发育的早期阶段是必需的。
The c-Myb transcription factor is important for fetal hematopoiesis and has been proposed to mediate later stages of lymphocyte development. Using homozygous null c-Myb/Rag1 chimeric mice, we have determined that c-Myb plays an important role in the differentiation of macrophages and lymphocytes from precursor stem cells. We also determine that deletion of c-Myb leads to a complete block in early T cell development just before the oligopotent thymocyte matures into the definitive T cell precursor. These data indicate that c-Myb plays an important role at multiple stages of hematopoiesis and is required at an early stage of T cell development.