Visual influences on diurnal rhythms in ocular length and choroidal thickness in chick eyes
Visual influences on diurnal rhythms in ocular length and choroidal thickness in chick eyes
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DOI：
10.1006/exer.1997.0420
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发表时间：
1998-02-01
影响因子：
3.4
通讯作者：
Wallman, J
中科院分区：
文献类型：
--
作者：
Nickla, DL;Wildsoet, C;Wallman, J
最近的研究提出了眼睛昼夜节律可能参与眼睛生长调节的可能性。具体来说，小鸡的眼睛以每天的节奏伸长，据说在形式剥夺的眼睛中是不存在的。本研究报告提出以下问题：（1）眼睛的哪些组成部分有日常节律-只有眼睛的整体大小，还是脉络膜厚度或前房深度？(2)这些节律的相位或幅度是否在眼睛生长比正常快（形觉剥夺眼）或比正常慢（从形觉剥夺近视恢复的眼睛）时有所不同？应用高频A型超声检查技术，对正常眼、形觉剥夺眼和形觉剥夺性近视眼进行了5天4夜的测量，测量时间间隔为6小时，测量前房深度、玻璃体腔深度、脉络膜厚度和眼轴长度。眼轴伸长和脉络膜厚度均呈日节律性变化。在正常和形式剥夺的眼睛，轴长是最大的下午脉络膜最薄的时候，因此，这些节奏大约在反相到另一个;此外，有一些证据表明，在形式剥夺的眼睛的轴长节奏是相位先进的相对于他们的同胞控制眼睛。形觉剥夺眼脉络膜厚度的节律幅度明显大于正常眼，而在恢复眼中，眼轴长度的节律相对于正常眼明显相位延迟（峰值在晚上8点），脉络膜厚度的节律相对于正常眼相位提前（峰值在晚上8点），因此，在这些眼中，这两种节律是同相的。在这些眼中，脉络膜增厚约100 μ m/天。在所有三组中，前房深度的节律似乎与眼轴长度的节律（因此与眼睛后壁的节律）在相位上不同。我们建议，这些脉络膜和眼睛长度的节奏之间的相位关系影响眼睛的生长速度，并得出结论，昼夜眼节律可能是重要的眼睛生长调节。(C)出版社：Academic Press Limited。
Recent investigations have raised the possibility that ocular diurnal rhythms might be involved in the regulation of eye growth. Specifically, the chick eye elongates with a daily rhythm, said to be absent in form-deprived eyes. The present study asks: (1) Which components of the eye have daily rhythms-only the overall eye size, or also choroidal thickness or anterior chamber depth? (2) Does the phase or amplitude of these rhythms differ in eyes growing either faster than normal (form-deprived eyes) or slower than normal (eyes recovering from form-deprivation myopia)?Using high-frequency A-scan ultrasonography that allowed fine (8-20 mu m) resolution of anterior chamber depth, vitreous chamber depth, choroidal thickness and axial length, we measured normal eyes, form-deprived eyes and eyes recovering from form-deprivation myopia at 6 hour intervals for 5 days and 4 nights. All eyes showed daily rhythms in axial elongation and choroidal thickness. In both normal and form-deprived eyes, the axial length was greatest in the afternoon when the choroid was thinnest, and hence, these rhythms were approximately in anti-phase to one another; in addition, there is some evidence that the axial length rhythm in form-deprived eyes is phase-advanced relative to that of their fellow control eyes. The amplitude of the rhythm in choroidal thickness in form-deprived eyes was significantly larger than in normal eyes.In recovering eyes in which elongation is slowed, the rhythm in axial length was significantly phase-delayed relative to normal eyes (peak at 8 pm) and the rhythm in choroidal thickness was phase-advanced (peak at 8 pm); thus in these eyes, the two rhythms are in phase. In these eyes, the choroids were thickening by approximately 100 mu m/day. In all three groups, the rhythm in anterior chamber depth appears to differ in phase from the rhythm in axial length (and hence from the rhythm at the posterior wall of the eye). We propose that the phase relationship between these choroidal and eye length rhythms influence the rate of growth of the eye, and conclude that diurnal ocular rhythms may be important in eye growth regulation. (C) 1998 Academic Press Limited.