Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol
Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol
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DOI：
10.1038/nrurol.2017.163
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发表时间：
2017-12-01
影响因子：
15.3
通讯作者：
Graf, Norbert
中科院分区：
文献类型：
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作者：
van den Heuvel-Eibrink, Marry M.;Hol, Janna A.;Graf, Norbert
国际儿科肿瘤学会肾肿瘤研究小组(SIOP-RTSG)制定了一项诊断和治疗儿童肾肿瘤的新方案，即SIOP-RTSG 2016(总体方案)，以继续在儿童肾肿瘤治疗方面进行国际合作。该方案将支持综合生物标记物和成像研究，重点评估肿瘤内基因组变化的独立预后价值以及在术前化疗中存活的胚基成分的体积。伞式方案中的肾母细胞瘤治疗指南包括针对所有年龄组和复发疾病的局部、转移和双侧疾病的建议。这些建议是由SIOP-RTSG内的肾脏肿瘤主要专家组成的多学科小组建立的。总括议定书应促进国际合作和研究，并作为SIOP-RTSG最佳可用的治疗标准。
The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP-RTSG 2016 (the UMBRELLA protocol), to continue international collaboration in the treatment of childhood renal tumours. This protocol will support integrated biomarker and imaging research, focussing on assessing the independent prognostic value of genomic changes within the tumour and the volume of the blastemal component that survives preoperative chemotherapy. Treatment guidelines for Wilms tumours in the UMBRELLA protocol include recommendations for localized, metastatic, and bilateral disease, for all age groups, and for relapsed disease. These recommendations have been established by a multidisciplinary panel of leading experts on renal tumours within the SIOP-RTSG. The UMBRELLA protocol should promote international collaboration and research and serve as the SIOP-RTSG best available treatment standard.