Progenitor cells in the pulmonary circulation.

Progenitor cells in the pulmonary circulation.
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肺循环中的祖细胞。

DOI:
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发表时间:
2011
期刊:
Proceedings of the American Thoracic Society
影响因子:
--
通讯作者:
M. Yoder
M. Yoder
中科院分区:
--
文献类型:
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作者:
M. Yoder

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尽管微血管和大血管内皮细胞之间的增殖潜力差异已被很好地描述,但对肺血管内皮细胞替代老化或损伤细胞的调节机制仍知之甚少。最近有报道在大鼠和小鼠中存在驻留的肺血管内皮祖细胞。这些驻留的内皮祖细胞在移植到受体动物后显示出克隆增殖潜力、细胞表面分子的表达限制为肺内皮典型分子,以及体内血管形成能力。大鼠肺微血管内皮细胞富含常驻祖细胞,与肺大血管内皮细胞相比具有最高的增殖潜力。初步证据表明,居民内皮祖细胞存在于人肺血管系统,但是否存在不同的肺血管床的祖细胞富集的差异仍有待确定。
The mechanisms involved in the regulation of pulmonary vascular endothelial cells to replace aged or injured cells remains poorly understood, although differences in proliferative potential between the microvascular and macrovascular endothelium are well described. The presence of resident pulmonary vascular endothelial progenitor cells in rats and mice has been recently reported. These resident endothelial progenitor cells display clonal proliferative potential, restricted expression of cell surface molecules to those typical of lung endothelium, and in vivo vessel-forming ability upon transplantation into recipient animals. The rat pulmonary microvascular endothelium is enriched in resident progenitor cells, with the highest proliferative potential compared with the pulmonary macrovascular endothelium. Preliminary evidence suggests that resident endothelial progenitor cells are present in the human lung vasculature, but whether differences in enrichment of the progenitors in various pulmonary vascular beds exist remains to be determined.
白鸽动脉粥样硬化病变的内皮细胞增殖和单核细胞粘附。
DOI: --
发表时间: 1986
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