Role of complement in induction of antibody production in vivo. Effect of cobra factor and other C3-reactive agents on thymus-dependent and thymus-independent antibody responses.
Role of complement in induction of antibody production in vivo. Effect of cobra factor and other C3-reactive agents on thymus-dependent and thymus-independent antibody responses.
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DOI：
10.1084/jem.140.1.126
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发表时间：
1974-07-01
影响因子：
15.3
通讯作者：
Pepys, M B
中科院分区：
文献类型：
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作者：
Pepys, M B
在小鼠体内的研究中，眼镜蛇毒素(COF)的C3裂解蛋白和其他C3反应剂(酵母多糖、聚集的免疫球蛋白、抗C3抗体和III型肺炎球菌多糖)抑制了对绵羊红细胞、卵白蛋白和人免疫球蛋白的胸腺依赖抗体反应。然而，COF不影响对聚乙烯吡咯烷酮的胸腺非依赖性抗体反应。这些和其他已发表的观察结果表明，在诱导胸腺依赖而不是胸腺非依赖的抗体产生时，可能需要功能性C3。在这些数据的基础上，根据已有的关于这一过程的知识，提出了一个关于C3在淋巴细胞合作中的作用的模型。据推测，固定的C3与巨噬细胞相互作用，结构见PDF，B细胞C3受体可能增强或促进T细胞向B细胞递呈抗原。
In an in vivo study in mice, suppression by the C3-cleaving protein of cobra venom (CoF), and other C3-reactive agents (zymosan, aggregated IgG, anti-C3 antibodies, and type III pneumococcal polysaccharide) of the thymus-dependent antibody responses to sheep erythrocytes, ovalbumin, and human IgG was demonstrated. The thymus-independent antibody response to polyvinyl-pyrrolidone was however unaffected by CoF. These and other published observations suggest that there may be a requirement for functional C3 in induction of thymus-dependent but not thymus-independent antibody production. A model for the role of C3 in lymphocyte cooperation is proposed based on these data analyzed in the light of existing knowledge of this process. It is postulated that fixed C3 interacting with macrophage See PDF for Structure and B-cell C3 receptors might enhance or facilitate T-dependent presentation of antigen to B cells.