DIFFERENCE IN THE PHENOTYPES OF BRONCHOALVEOLAR LAVAGE LYMPHOCYTES IN PATIENTS WITH SUMMER-TYPE HYPERSENSITIVITY PNEUMONITIS, FARMERS LUNG, VENTILATION PNEUMONITIS, AND BIRD FANCIERS LUNG - REPORT OF A NATIONWIDE EPIDEMIOLOGIC-STUDY IN JAPAN
DIFFERENCE IN THE PHENOTYPES OF BRONCHOALVEOLAR LAVAGE LYMPHOCYTES IN PATIENTS WITH SUMMER-TYPE HYPERSENSITIVITY PNEUMONITIS, FARMERS LUNG, VENTILATION PNEUMONITIS, AND BIRD FANCIERS LUNG - REPORT OF A NATIONWIDE EPIDEMIOLOGIC-STUDY IN JAPAN
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DOI：
10.1016/0091-6749(91)90423-l
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发表时间：
1991-05-01
影响因子：
14.2
通讯作者：
TAMURA, M
中科院分区：
文献类型：
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作者：
ANDO, M;KONISHI, K;TAMURA, M
我们通过问卷调查在日本进行了一项全国范围的过敏性肺炎（HP）流行病学研究，发现在20世纪80年代有835例HP病例被确认;夏季型HP占74.4%，农民肺占8.1%，通气性肺炎占4.3%，养鸟者肺占4.1%，其他类型如化工工人肺占2.3%，不明原因者占6.8%。 结果发现，支气管肺泡灌洗（BAL）淋巴细胞CD_4/CD_8比值随疾病类型不同而有显著差异。 该比值在夏季型HP（N = 271）中为0.6 +/- 0.1（平均值+/- SEM），农民肺（N = 22）中为4.4 +/- 0.7，通气性肺炎（N = 19）中为1.6 +/- 0.3，鸟类爱好者肺（N = 19）中为2.0 +/- 0.5。 在农民肺中，吸烟者的CD 4/CD 8比率为6.2 +/-1.9（N = 6），而非吸烟者为3.4 +/-0.7（N = 16）（p < 0.05）。 一般认为HP患者的BAL淋巴细胞表型以CD 8细胞为主。 然而，我们目前的研究结果表明，BAL淋巴细胞的表型与HP的类型不同，可能取决于因素，如病原体，吸烟，或分期的疾病。
We performed a nationwide epidemiologic study of hypersensitivity pneumonitis (HP) in Japan by questionnaire and found that 835 cases of HP were recognized during the 1980s; 74.4% were summer-type HP, 8.1% farmer's lung, 4.3% ventilation pneumonitis, 4.1% bird fancier's lung, 2.3% other types, such as chemical worker's lung, and 6.8% of unknown causative agent. It was found that the CD4/CD8 ratios of bronchoalveolar lavage (BAL) lymphocytes were significantly different with the type of disease. The ratio was 0.6 +/- 0.1 (mean +/- SEM) in summer-type HP (N = 271), 4.4 +/- 0.7 in farmer's lung (N = 22), 1.6 +/- 0.3 in ventilation pneumonitis (N = 19), and 2.0 +/- 0.5 in bird fancier's lung (N = 19). In farmer's lung, the CD4/CD8 ratio in smokers was 6.2 +/- 1.9 (N = 6) in contrast with 3.4 +/- 0.7 for nonsmokers (N = 16) (p < 0.05). It has been generally considered that the phenotypes of BAL lymphocytes in patients with HP are predominately CD8 cells. Our present results, however indicate that the phenotypes of BAL lymphocytes vary with the type of HP, probably depending on factors such as causative agent, smoking, or staging of the disease.