Squatting, Sitting on the Floor, or Cycling: Are Life-Long Daily Activities Risk Factors for Clinical Knee Osteoarthritis? Stage III Results of a Community-Based Study
Squatting, Sitting on the Floor, or Cycling: Are Life-Long Daily Activities Risk Factors for Clinical Knee Osteoarthritis? Stage III Results of a Community-Based Study
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DOI：
10.1002/art.24737
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发表时间：
2009-10-01
影响因子：
4.7
通讯作者：
Davatchi, F.
中科院分区：
文献类型：
--
作者：
Dahaghin, S.;Tehrani-Banihashemi, S. A.;Davatchi, F.
目标。评估职业、运动、终生日常活动与膝关节骨关节炎之间的关系。在这项病例对照研究中，我们随机招募了480名膝关节骨关节炎患者，他们参加了德黑兰社区研究的第一阶段，并将他们与490名对照组进行了比较。调查问卷记录了所有职业、运动和10项日常活动的细节。以最轻的活动为参考，计算和比较这些活动花费的平均+/- SD小时/天。采用广义估计方程，以各膝关节为分析单位。平均+/- SD年龄和女性分布百分比为57 +/- 12岁，69.8%为病例，46.8 +/- 15岁，64.1%为对照组。在调整了年龄、性别和体重指数后，2项活动是膝关节骨关节炎的危险因素：长时间深蹲（优势比[OR] 1.51, 95%可信区间[95% CI] 1.12-2.04）和骑车（优势比[OR] 2.06, 95% CI 1.23-3.45）。膝关节弯曲具有临界意义（OR 1.98, 95% CI 0.98-3.99）。负重（OR 1.24, 95% CI 0.87-1.76）或爬楼梯（OR 0.99, 95% CI 0.69-1.42）没有显示膝关节骨关节炎的额外风险。长时间站立、坐在地板上和上下行走对膝骨关节炎没有风险。家庭主妇患膝骨关节炎的风险（临界显著性）高于主要职业以外的妇女（OR 1.68, 95% CI 0.93-3.03）。其他类型的工作和运动并没有显示出膝关节骨关节炎的额外风险。我们的研究结果支持了生活方式在深蹲和骑车引起的膝骨关节炎发病机制中的作用。应考虑对可预防的危险因素进行教育，以确保人们正确使用膝关节，避免过度使用。
Objective. To evaluate the association between occupations, sports, life-long daily activities, and knee osteoarthritis.Methods. In this case-control study, we randomly recruited 480 subjects with knee osteoarthritis, who had participated in the first stage of a community-based study in Tehran, and compared them with 490 controls. A questionnaire was used to record all occupations, sports, and the details of 10 daily activities. The mean +/- SD hours/day spent on these activities were calculated and compared using the lightest activity as reference. Generalized estimation equation was used with each knee as the unit of analysis.Results. The mean +/- SD age and percentage of female distribution was 57 +/- 12 years, 69.8% women for cases, and 46.8 +/- 15 years, 64.1% women for controls. After adjusting for age, sex, and body mass index, 2 activities were risk factors for knee osteoarthritis: prolonged squatting (odds ratio [OR] 1.51, 95% confidence interval [95% CI] 1.12-2.04) and cycling (OR 2.06, 95% CI 1.23-3.45). Knee-bending had borderline significance (OR 1.98, 95% CI 0.98-3.99). Carrying loads (OR 1.24, 95% CI 0.87-1.76) or climbing stairs (OR 0.99, 95% CI 0.69-1.42) showed no extra risk for knee osteoarthritis. Prolonged standing, sitting on the floor, and walking up/downhill were not risks for knee osteoarthritis. Housewives were at greater risk (borderline-significant) of developing knee osteoarthritis (OR 1.68, 95% CI 0.93-3.03) than women whose main occupation was outside the home. Other types of jobs and sports did not show an extra risk of knee osteoarthritis.Conclusion. Our findings support the role of lifestyle in the pathogenesis of knee osteoarthritis for squatting and cycling. Education on preventable risk factors should be considered in order to ensure people use knee joints appropriately and avoid overuse.