THE COALESCENT PROCESS AND BACKGROUND SELECTION
THE COALESCENT PROCESS AND BACKGROUND SELECTION
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DOI：
10.1098/rstb.1995.0086
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发表时间：
1995-07-29
影响因子：
6.3
通讯作者：
KAPLAN, NL
中科院分区：
文献类型：
--
作者：
HUDSON, RR;KAPLAN, NL
描述了具有背景有害突变模型的基因树的一些统计性质。有人认为，在这个模型下的一个小样本的基因的历史是一个连续的时间马尔可夫链，迅速达到平稳。这一观察结果导致了预期的核苷酸多样性的简单表达式，并表明小样本中的频谱应该与严格中性模型下的频谱大致相同。关于预期的核苷酸多样性的结果进行了比较与观察到的变化，果蝇的第三条染色体。
Some statistical properties of gene trees are described for a model with background deleterious mutations. It is argued that the history of a small sample of genes under this model is a continuous time Markov chain that quickly reaches stationarity. This observation leads to simple expressions for the expected nucleotide diversity and suggests that the frequency spectrum in small samples should be approximately the same as under a strict neutral model. The results concerning expected nucleotide diversity are compared with observed variation on the third chromosome of Drosophila melanogaster.