Modification of acrylic bone cement with mesoporous silica nanoparticles: Effects on mechanical, fatigue and absorption properties
Modification of acrylic bone cement with mesoporous silica nanoparticles: Effects on mechanical, fatigue and absorption properties
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DOI：
10.1016/j.jmbbm.2013.10.008
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发表时间：
2014-01-01
影响因子：
3.9
通讯作者：
Squire, Matthew
中科院分区：
文献类型：
--
作者：
Slane, Josh;Vivanco, Juan;Squire, Matthew
聚甲基丙烯酸甲酯骨水泥是将骨科植入物固定在骨上最常见和最成功的方法，这一点得到了长期国家关节登记数据的证明。尽管取得了这些成功，但水泥包套的机械故障可能导致植入物过早失效，这导致了各种旨在增强水泥机械性能的技术的发展，例如添加颗粒或纤维增强剂。然而，该技术尚未过渡到临床实践，可能是由于与界面颗粒/基质粘连和高水泥刚度相关的问题。介孔二氧化硅纳米颗粒（MSNs）是一类很少受到关注的材料，尽管它们具有克服这些挑战的潜在能力。因此，本研究的目的是研究介孔二氧化硅纳米颗粒（MSNs）作为丙烯酸骨水泥增强材料的使用。将三种不同的MSN加载比（0.5%、2%和5% (wt/wt)）加入到市售骨水泥中，并量化其对水泥静态力学性能、疲劳寿命和吸收/洗脱性能的影响。抗弯模量、抗压强度和模量随MSN浓度的增加而增加。相反，随着MSN含量的增加，抗弯强度、断裂韧性和断裂功均显著降低。疲劳性能受微球颗粒的影响很大，高微球颗粒载荷对疲劳性能有明显的不利影响。掺入5%的MSNs可显著提高水泥的水化度和洗脱率。结果表明，纳米颗粒与聚合物基体之间的界面粘附强度较差，导致弯曲和疲劳性能下降，或者纳米颗粒没有得到充分的分散。这些发现可能会在未来的工作中通过用官能团对介孔二氧化硅进行化学修饰来减轻。(C) 2013 Elsevier Ltd.版权所有。
Polymethyl methacrylate bone cement is the most common and successful method used to anchor orthopedic implants to bone, as evidenced by data from long-term national joint registries. Despite these successes, mechanical failure of the cement mantle can result in premature failure of an implant which has lead to the development of a variety of techniques aimed at enhancing the mechanical properties of the cement, such as the addition of particulate or fiber reinforcements. This technique however has not transitioned into clinical practice, likely due to problems relating to interfacial particle/matrix adhesion and high cement stiffness. Mesoporous silica nanoparticles (MSNs) are a class of materials that have received little attention as polymer reinforcements despite their potential ability to overcome these challenges. Therefore, the objective of the present study was to investigate the use of mesoporous silica nanoparticles (MSNs) as a reinforcement material within acrylic bone cement. Three different MSN loading ratios (0.5%, 2% and 5% (wt/wt)) were incorporated into a commercially available bone cement and the resulting impact on the cement's static mechanical properties, fatigue life and absorption/elution properties were quantified. The flexural modulus and compressive strength and modulus tended to increase with higher MSN concentration. Conversely, the flexural strength, fracture toughness and work to fracture all significantly decreased with increasing MSN content. The fatigue properties were found to be highly influenced by MSNs, with substantial detrimental effects seen with high MSN loadings. The incorporation of 5% MSNs significantly increased cement's hydration degree and elution percentage. The obtained results suggest that the interfacial adhesion strength between the nanoparticles and the polymer matrix was poor, leading to a decrease in the flexural and fatigue properties, or that adequate dispersion of the MSNs was not achieved. These findings could potentially be mitigated in future work by chemically modifying the mesoporous silica with functional groups. (C) 2013 Elsevier Ltd. All rights reserved.