Update on fatty liver disease and steatohepatitis.
Update on fatty liver disease and steatohepatitis.
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DOI：
10.1097/pap.0b013e318220f59b
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发表时间：
2011-07
影响因子：
6.7
通讯作者：
Kleiner DE
中科院分区：
文献类型：
--
作者：
Aly FZ;Kleiner DE
非酒精性脂肪性肝病(NAFLD)是一个广义的术语，包括肝脏疾病，其特征是肝细胞脂质异常堆积，与酗酒无关。无论是成人还是儿童，尤其是肥胖或有胰岛素抵抗的人，都可能会发现这种情况。脂肪性肝炎是NAFLD范围内的一种特殊的损伤类型，这种类型与纤维化进展和肝硬变有关。除脂肪性肝炎外，儿童中还存在一种独特的纤维性脂肪性肝病。在描述NAFLD的组织学变化方面有一些最新的进展。根据这些最新报道，本研究将：(1)综述成人脂肪变性和非酒精性脂肪性肝炎的组织学特征；(2)综述儿童脂肪性肝病组织学类型的变化；(3)讨论非酒精性脂肪性肝病活动评分的有效性和用途。
Non-alcoholic fatty liver disease (NAFLD) is a broad term that includes liver diseases characterized by abnormal hepatocellular accumulations of lipid that cannot be related to alcohol abuse. It may be found in both adults and children, particularly those who are obese or have insulin resistance. Steatohepatitis is a specific pattern of injury within the spectrum of NAFLD and this pattern is associated with fibrotic progression and cirrhosis. In addition to steatohepatitis, a distinct form of fibrotic fatty liver disease exists in children. There have been a number of recent advances in the characterization of histologic changes in NAFLD. In light of these recent reports, this study will:(1) review the histologic features of steatosis and nonalcoholic steatohepatitis in adults;(2) review the variation of histologic patterns of pediatric fatty liver disease; and (3) discuss the validity and use of the nonalcoholic fatty liver disease Activity Score.