Dietary intake and bioavailability of polyphenols
Dietary intake and bioavailability of polyphenols
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DOI：
10.1093/jn/130.8.2073s
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发表时间：
2000-08-01
影响因子：
4.2
通讯作者：
Williamson, G
中科院分区：
文献类型：
--
作者：
Scalbert, A;Williamson, G
综述了多酚的主要膳食来源，并计算了含有一些常见水果、蔬菜和饮料的给定膳食的每日摄入量。酚酸约占总摄入量的三分之一，类黄酮占其余三分之二。饮食中最丰富的类黄酮是黄烷醇（儿茶素加上原花青素），花青素及其氧化产物。多酚的主要膳食来源是水果和饮料（果汁、葡萄酒、茶、咖啡、巧克力和啤酒），以及较少程度的蔬菜、干豆类和谷物。总摄入量接近1 g/d。由于食品中一些主要多酚类含量的综合数据的粘性，仍然存在很大的不确定性。讨论了人体生物利用度研究。在摄入10-100 mg单一酚类化合物后，血浆中的最大浓度很少超过1 μ M。然而，总血浆苯酚浓度可能较高，这是由于存在体内组织或结肠微生物菌群形成的代谢物。这些代谢物在很大程度上仍然是未知的，不占，无论是化学和生物化学因素影响的吸收和代谢的多酚进行审查，特别强调黄酮苷。更好地了解这些因素是必不可少的，以解释在多酚和个人之间观察到的生物利用度的巨大变化。
The main dietary sources of polyphenols are reviewed, and the daily intake is calculated for a given diet containing some common fruits, vegetables and beverages. Phenolic acids account for about one third of the total intake and flavonoids account for the remaining two thirds. The most abundant flavonoids in the diet are flavanols (catechins plus proanthocyanidins), anthocyanins and their oxidation products. The main polyphenol dietary sources are fruit and beverages (fruit juice, wine, tea, coffee, chocolate and beer) and, to a lesser extent vegetables, dry legumes and cereals. The total intake is similar to 1 g/d. Large uncertainties remain due to the tack of comprehensive data on the content of some of the main polyphenol classes in food. Bioavailability studies in humans are discussed. The maximum concentration in plasma rarely exceeds 1 mu M after the consumption of 10-100 mg of a single phenolic compound. However, the total plasma phenol concentration is probably higher due to the presence of metabolites formed in the body's tissues or by the colonic microflora. These metabolites are still largely unknown and not accounted for, Both chemical and biochemical factors that affect the absorption and metabolism of polyphenols are reviewed, with particular emphasis on flavonoid glycosides. A better understanding of these factors is essential to explain the large variations in bioavailability observed among polyphenols and among individuals.