Positron imaging feasibility studies: selective tumor concentration of 3H-thymidine, 3H-uridine, and 14C-2-deoxyglucose.
Positron imaging feasibility studies: selective tumor concentration of 3H-thymidine, 3H-uridine, and 14C-2-deoxyglucose.
复制标题
正电子成像可行性研究：3H-胸苷、3H-尿苷和14C-2-脱氧葡萄糖的选择性肿瘤浓度。
作者：
S. Larson;Z. Grunbaum;J. Rasey
将糖酵解和核酸合成的底物作为肿瘤显像剂与67Ga-柠檬酸盐进行了比较。分别对荷EMT-6肉瘤的BALB/c小鼠静脉注射~3H-胸腺嘧啶核苷、~3H-尿苷、~(14)C-2-脱氧葡萄糖和67Ga-柠檬酸。对于~3H和~(14)C标记的底物，肿瘤的绝对摄取率和肿瘤与血液的比率在注射后1小时与67Ga-柠檬酸盐在48小时后达到的可比最大值一样高。这些研究表明，正电子标记的胸苷、尿苷和2-脱氧葡萄糖的类似物应该是通过正电子发射断层扫描进行肿瘤成像的有用的放射性药物。
The potential usefulness of substrates for glycolysis and nucleic acid synthesis as tumor imaging agents was compared to that of 67Ga-citrate. In separate experiments, 3H-thymidine, 3H-uridine, 14C-2-deoxyglucose, and 67Ga-citrate were injected intraveneously into BALB/c mice with solid subcutaneous EMT-6 sarcomas. For the 3H- and 14C-labeled substrates, absolute uptakes in tumor and tumor-to-blood ratios were as high 1 hour after injection as the comparable maximum values achieved for 67Ga-citrate after 48 hours. These studies suggest that positron-labeled analogues of thymidine, uridine, and 2-deoxyglucose should be useful radiopharmaceuticals for tumor imaging by positron-emission tomography.