Unique cytological features and chromosome aberrations in chondroid lipoma -: A case report based on fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and molecular cytogenetics
Unique cytological features and chromosome aberrations in chondroid lipoma -: A case report based on fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and molecular cytogenetics
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DOI：
10.1097/00000478-199910000-00018
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发表时间：
1999-10-01
影响因子：
5.6
通讯作者：
Mandahl, N
中科院分区：
文献类型：
--
作者：
Gisselsson, D;Domanski, HA;Mandahl, N
软骨样脂肪瘤是一种罕见的良性肿瘤，临床上可能类似于软组织肉瘤。其组织病理学特征可能类似于冬眠瘤、粘液样脂肪肉瘤、粘液样软骨肉瘤和其他脂肪瘤或软骨样肿瘤。在这项研究中，通过细针抽吸细胞学、组织病理学、电子显微镜、染色体显带和中期荧光原位杂交对软骨样脂肪瘤进行了分析。结果表明，通过细针抽吸细胞学检查，软骨样脂肪瘤表现出特征性模式，包括良性脂肪组织与脂肪母细胞样细胞的混合物，以及软骨母细胞样细胞与纤维软骨样基质的混合物。在细胞遗传学上，发现了 1、2 和 5 号染色体之间的三向重排，以及 11;16 易位，该易位位于 11q13（靠近 MEN1 区域约 1 Mb）处，显示在冬眠瘤中频繁重排。低复杂性核型的存在，但没有任何其他类型软组织肿瘤特有的遗传畸变，表明软骨样脂肪瘤沿着独特的发病途径发展。
Chondroid lipoma is a rare, benign tumor that may mimic soft-tissue sarcoma clinically. Its histopathologic features may resemble hibernoma, myxoid liposarcoma, myxoid chondrosarcoma, and other lipomatous or chondroid neoplasms. In this study, a chondroid lipoma was analyzed by fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and metaphase fluorescence in situ hybridization. The results demonstrate that chondroid lipoma exhibits a characteristic pattern by fine-needle aspiration cytology, including a mixture of benign adipose tissue with lipoblastlike cells, and chondroblastlike cells with a fibrochondroid matrix. Cytogenetically, a three-way rearrangement between chromosomes 1, 2, and 5 was found, together with an 11;16 translocation with a breakpoint in 11q13, approximately 1 Mb proximal to the MEN1 region shown to be rearranged frequently in hibernoma. The presence of a karyotype of low complexity, but without any of the genetic aberrations characteristic for other types of soft-tissue tumors, indicate that chondroid lipoma develops along a unique pathogenetic pathway.