Autoradiographic and fluorescence antibody studies of the human host immune response to gliomas
Autoradiographic and fluorescence antibody studies of the human host immune response to gliomas
复制标题
人类宿主对神经胶质瘤免疫反应的放射自显影和荧光抗体研究
作者：
A. Eggers
最近提出了对肿瘤的两阶段免疫反应的理论。第一阶段被认为是由淋巴细胞介导的，淋巴细胞对肿瘤抗原特别敏感，可能会摧毁肿瘤，从而终止疾病，或者对于临床表现明显的肿瘤，在覆盖肿瘤并将其隐藏在淋巴细胞之外的“增强抗体”出现之前，可能没有足够数量的淋巴细胞动员起来。由于中枢神经系统是一个免疫“特权部位”2，没有淋巴引流，对胶质瘤的任何两个阶段的反应似乎都可能减慢，结果是肿瘤可能在特定致敏的淋巴细胞出现后和增强抗体出现之前出现临床症状。一份报告描述了组织培养中胶质母细胞瘤细胞对自体淋巴细胞的放射自显影刺激，其中肿瘤细胞产生的刺激介于植物血凝素产生的刺激和自体成纤维细胞产生的刺激之间。3进一步探索了这个实验系统，结果与荧光抗体结果相关联。
A THEORY of a two-stage immunological response to neoplasia has recently been proposed.’ The first stage is held to be mediated by lymphocytes which are specifically sensitized to tumor antigens and may destroy the tumor, thus aborting the disease, or which, in the case of tumors that become clinically apparent, may not be mobilized in sufficient quantities before the appearance of “enhancing antibodies” that coat the tumor and hide it from the lymphocytes. Because the CNS is an immunologically “privileged site”2 with no lymphatic drainage, it seemed possible that any two-stage response to gliomas might be slowed, with the result that the tumors might become clinically apparent after the appearance of specifically sensitized lymphocytes and before the appearance of enhancing antibodies. A report has appeared describing the autoradiographically detected stimulation of autologus lymphocytes by glioblastoma cells in tissue culture, where the tumor cells produced stimulation intermediate between that produced by phytohemagglutinin and that produced by autologus fibroblasts.3 This experimental system was further explored, and the results were correlated with fluorescence antibody findings.