Modeling pulsed magnetization transfer
Modeling pulsed magnetization transfer
复制标题
DOI：
10.1002/mrm.21244
复制
发表时间：
2007-07-01
影响因子：
3.3
通讯作者：
Stanisz, Greg J.
中科院分区：
文献类型：
--
作者：
Portnoy, Sharon;Stanisz, Greg J.
模拟临床磁化转移（MT）扫描的效果，使用短的，成形的射频（RF）脉冲（脉冲MT）生成对比度，是复杂和耗时的。因此，一些研究已经提出了近似的方法来简化实验数据的分析。然而，在MT参数估计的每种方法的潜在差异可能会复杂的报告结果的比较。在这项研究中，我们评估了目前用于定量MT（qMT）研究的三种近似方法。在调查的第一部分，MT建模技术，使最小的近似值，而不是使用一个两池组织表示，开发和验证。随后，这种技术作为一个标准，以评估其他更近似的模型。每个模型用于拟合来自野生型（WT）和颤抖小鼠脊髓样品的实验数据，以及由我们的最小近似建模技术生成的模拟数据。本研究的结果表明，在脉冲MT建模中使用的近似是相当强大的。特别是，它表明，半固体池部分，MO B，这是已知的强烈相关的髓鞘含量，和横向弛豫时间的大分子质子，T-2（B），可以评估与合理的精度，无论使用的模型。Magn Reson Med 58：144-155，2007年。(c)2007 Wiley-Liss，Inc.
Modeling the effects of clinical magnetization transfer (MT) scans, which generate contrast using short, shaped radio-frequency (RF) pulses (pulsed MT), is complex and time-consuming. As a result, several studies have proposed approximate methods for a simplified analysis of the experimental data. However, potential differences in the MT parameters estimated by each method may complicate the comparison of reported results. In this study we evaluated three approximate methods currently used in quantitative MT (qMT) studies. In the first part of the investigation, an MT modeling technique that makes minimal approximations, other than the use of a two-pool tissue representation, was developed and validated. Subsequently, this technique served as a standard against which to evaluate the other, more approximate models. Each model was used to fit experimental data from samples of wild-type (WT) and shiverer mouse spinal cord, as well as simulated data generated by our minimal approximation modeling technique. The results of this study demonstrate that the approximations used in pulsed MT modeling are quite robust. In particular, it was shown that the semisolid pool fraction, MOB, which is known to correlate strongly with myelin content, and the transverse relaxation time of macromolecular protons, T-2(B), could be evaluated with reasonable accuracy regardless of the model used. Magn Reson Med 58:144-155, 2007. (c) 2007 Wiley-Liss, Inc.