MIXED ORGANIC BRAIN-SYNDROME AS A MANIFESTATION OF SYSTEMIC MASTOCYTOSIS
MIXED ORGANIC BRAIN-SYNDROME AS A MANIFESTATION OF SYSTEMIC MASTOCYTOSIS
复制标题
DOI：
10.1097/00006842-198607000-00006
复制
发表时间：
1986-07-01
影响因子：
3.3
通讯作者：
AUSTEN, KF
中科院分区：
文献类型：
--
作者：
ROGERS, MP;BLOOMINGDALE, K;AUSTEN, KF
系统性肥大细胞增多症是一种以肥大细胞过度积聚为特征的疾病，并与皮肤病变、潮红、腹泻、心动过速和精神症状有关。为了更清楚地定义精神症状，10例患有这种疾病的患者接受了非结构化精神病学访谈和一系列心理测试。两者都揭示了大多数患者的认知和情感变化模式，最好归类为非典型或混合器质性脑综合征。认知变化包括注意力和记忆力下降，以及愤怒、易怒和抑郁（程度较轻）等情感变化。这些表现随疾病活动水平而波动，在某些情况下出现对组胺拮抗剂和色甘酸二钠（用于控制肥大细胞过度活动的药物）的反应。重要的是，精神科医生要意识到，精神状态的变化可以代表精神表现的细胞增多症，一个容易治疗的医学疾病。
Systemic mastocytosis is a disease characterized by an excessive accumulation of mast cells, and associated with skin lesions, flushing, diarrhea, tachycardia, and psychiatric manifestations. In order to define more clearly the psychiatric manifestations, ten patients with this disorder underwent unstructured psychiatric interviews and a battery of psychologic testing. Both revealed a pattern of cognitive and affective changes in the majority of these patients, best categorized as an atypical or mixed organic brain syndrome. The cognitive changes consisted of diminished attention and memory, and the affective changes of anger, irritability, and, to a lesser extent, depression. These manifestations fluctuated with the level of disease activity, and appeared in some cases to respond to histamine antagonists and disodium cromoglycate, medications used to control the excessive mast cell activity. It is important for psychiatrists to be aware that mental status changes can represent psychiatric manifestations of matocytosis, a readily treatable medical disorder.