The Use of Commercially Available Alpha-Amylase Compounds to Inhibit and Remove Staphylococcus aureus Biofilms.
The Use of Commercially Available Alpha-Amylase Compounds to Inhibit and Remove Staphylococcus aureus Biofilms.
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DOI：
10.2174/1874285801105010021
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Kadouri DE
中科院分区：
文献类型：
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作者：
Craigen B;Dashiff A;Kadouri DE
金黄色葡萄球菌是一种多用途的人类病原体，通常与医疗器械感染有关。它建立和维持这些感染的能力被认为与它形成粘附生物膜的能力有关。在这项研究中，我们评估了来自不同生物来源的市售α-淀粉酶化合物减少和阻止几种金黄色葡萄球菌分离株生物膜形成的能力。结果表明，α-淀粉酶化合物能够快速分离金黄色葡萄球菌的生物膜，并抑制生物膜的形成。我们的数据还表明，α-淀粉酶化合物具有减少和分离液体悬浮液中生长的金黄色葡萄球菌细胞聚集体的能力。这些发现表明，市售α-淀粉酶化合物可以在未来用于控制金黄色葡萄球菌生物膜相关感染。
Staphylococcus aureus, a versatile human pathogen, is commonly associated with medical device infections. Its capacity to establish and maintain these infections is thought to be related to its ability to form adherent biofilms. In this study, commercially available α-amylase compounds from various biological sources were evaluated for their ability to reduce and prevent biofilm formation of several S. aureus isolates. Our data demonstrates that α-amylase compounds can rapidly detach biofilms of S. aureus, as well as inhibit biofilm formation. Our data also demonstrates that α-amylase compounds have an ability to reduce and disassociate S. aureus cell-aggregates grown in liquid suspension. These findings suggest that commercially available α-amylase compounds could be used in the future to control S. aureus biofilm-related infections.