Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications
Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications
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DOI：
10.1016/j.oooo.2018.03.012
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发表时间：
2018-06-01
影响因子：
2.9
通讯作者：
Sauk, John J.
中科院分区：
文献类型：
--
作者：
Nikitakis, Nikolaos G.;Pentenero, Monica;Sauk, John J.
识别和管理具有最高恶性转化风险的潜在癌前口腔上皮病变（poels），对于成功预防口腔鳞状细胞癌具有很大的希望，有可能降低口腔癌的发病率和死亡率。然而，迄今为止，无论是临床还是组织病理学验证的风险预测因素都不能可靠地预测哪些PPOELs最终会发展为恶性肿瘤。此外，ppoel的管理仍然是一个重大挑战。可以说，预防和治疗口腔恶性前病变和癌症的进展将需要提高对潜在分子机制的理解，促进发现诊断、预后和预测标志物，以及确定新的靶向治疗方法。本文综述了在PPOELs中研究的分子生物标志物，这些标志物与发育不良的存在和分级以及/或其向口腔鳞状细胞癌恶性转化的倾向相关。重点是突出新兴的研究领域，特别是表观遗传事件，包括甲基化和微rna调控。重点介绍了几种有前景的生物标志物。讨论了当前的限制和挑战。提出了未来重点研究领域的建议，以验证和促进临床有用的应用。
Identification and management of potentially premalignant oral epithelial lesions (PPOELs) at highest risk of malignant transformation holds great promise for successful secondary prevention of oral squamous cell carcinoma, potentially reducing oral cancer morbidity and mortality. I however, to date, neither clinical nor histopathologic validated risk predictors that can reliably predict which PPOELs will definitively progress to malignancy have been identified. In addition, the management of PPOELs remains a major challenge. Arguably, progress in the prevention and treatment of oral premalignancy and cancer will require improved understanding of the underlying molecular mechanisms, facilitating the discovery of diagnostic, prognostic, and predictive markers, as well as the identification of novel targeted therapeutics.This review provides a synopsis of the molecular biomarkers that have been studied in PPOELs and have been correlated with the presence and grade of dysplasia and/or their propensity to undergo malignant transformation to oral squamous cell carcinoma. The emphasis is on highlighting new emerging research fields, particularly epigenetic events, including methylation and micro-RNA regulation. Several promising biomarkers are highlighted. Current limitations and challenges are discussed. Recommendations for future focused research areas, to validate and promote clinically useful applications, are offered.