Biomechanical factors in tissue engineered meniscal repair.
Biomechanical factors in tissue engineered meniscal repair.
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DOI：
10.1097/00003086-199910001-00025
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发表时间：
1999-10
影响因子：
4.2
通讯作者：
L. Setton;F. Guilak;E. Hsu;T. Vail
中科院分区：
文献类型：
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作者：
L. Setton;F. Guilak;E. Hsu;T. Vail
创伤或损伤后半月板损伤与关节功能的有害变化相关，可导致疼痛、残疾和退行性关节变化。最近，已经提出了用于椎间盘修复的组织工程策略，包括使用生物相容性移植物作为再生基质，以及细胞补充以促进重塑和愈合。然而，关于这些新的修复策略对恢复正常神经功能的贡献，我们知之甚少。生物力学因素在组织工程生物材料和生物反应器的设计和合成中起着重要作用，并且对于评估这些恢复正常骨骼功能的新策略的有效性也很重要。在这份报告中，概述了生物力学因素，是至关重要的，由生物力学的考虑，设计和评价组织工程的策略，修复后的审查。并对组织工程骨缺损修复中生物力学因素的研究提出了建议。
Damage to the meniscus after trauma or injury is associated with detrimental changes in joint function that can lead to pain, disability, and degenerative joint changes. Recently, tissue engineering strategies for meniscal repair have been suggested including using biocompatible grafts as a substrate for regeneration, and cellular supplementation to promote remodeling and healing. Little is known, however, about the contributions of these novel repair strategies to restoration of normal meniscal function. Biomechanical factors play a role in the design and synthesis of tissue engineered biomaterials and bioreactors, and also are important for evaluating the efficacy of these new strategies for restoring normal meniscal function. In this report, an overview is presented of biomechanical factors that are critical to meniscal function followed by a review of biomechanical considerations for the design and evaluation of tissue engineered strategies for meniscal repair. Recommendations for future study of biomechanical factors in tissue engineered meniscal repair also are provided.