Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins.
Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins.
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DOI：
10.1176/ajp.149.7.890
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发表时间：
1992-07
期刊：
影响因子：
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通讯作者：
D. Weinberger;K. Berman;R. Suddath;E. Torrey
中科院分区：
文献类型：
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作者：
D. Weinberger;K. Berman;R. Suddath;E. Torrey
目的作者先前报道，在精神分裂症的同卵双胞胎中，通过磁共振成像(MRI)测量，患病双胞胎几乎总是有较小的前PES海马体，并且在进行威斯康星卡片分类测试时，总是有较少的前额叶背外侧皮质局部脑血流量(RCBF)。本研究旨在探讨同一对双生子海马区病理改变与前额叶功能减退的关系。方法对9对符合精神分裂症诊断标准的同卵双生子进行了海马区前部体积的MRI扫描，并结合威斯康星卡片分类试验进行了氙气吸入rCBF试验。结果双生子在MRI和rCBF测量上的差异具有很强的选择性相关性。具体地说，在威斯康星卡片分类测试中，受影响的双胞胎与未受影响的双胞胎在左侧海马体体积上的差异越大，他们在前额叶生理激活方面的差异就越大。在受影响的双胞胎中，作为一个组，前额叶激活与左侧和右侧海马体体积都有很强的相关性。这些关系在未受影响的双胞胎组中没有发现。结论这一发现与精神分裂症涉及广泛分布的新皮质-边缘神经网络的病理和功能障碍的概念是一致的，该网络与需要工作记忆的认知任务的执行等活动有关。
OBJECTIVE The authors previously reported that in monozygotic twins discordant for schizophrenia the affected twin almost invariably had a smaller anterior pes hippocampus, measured with magnetic resonance imaging (MRI), and invariably had less regional cerebral blood flow (rCBF) in the dorsolateral prefrontal cortex during performance of the Wisconsin Card Sorting Test. The present study was an investigation of the relationship between hippocampal pathology and prefrontal hypofunction in the same twin pairs. METHOD Nine pairs of monozygotic twins discordant for schizophrenia underwent MRI scanning for determination of anterior hippocampal volume and xenon-inhalation rCBF testing for determination of prefrontal physiological activation associated with the Wisconsin Card Sorting Test. RESULTS The differences within twin pairs on the MRI and rCBF measures were strongly and selectively correlated. Specifically, the more an affected twin differed from the unaffected twin in left hippocampal volume, the more they differed in prefrontal physiological activation during the Wisconsin Card Sorting Test. In the affected twins as a group, prefrontal activation was strongly related to both left and right hippocampal volume. These relationships were not found in the group of unaffected twins. CONCLUSIONS This finding is consistent with the notion that schizophrenia involves pathology of and dysfunction within a widely distributed neocortical-limbic neural network that has been implicated in, among other activities, the performance of cognitive tasks requiring working memory.