Variant chromatin structure of the oriP region of Epstein-Barr virus and regulation of EBER1 expression by upstream sequences and oriP
Variant chromatin structure of the oriP region of Epstein-Barr virus and regulation of EBER1 expression by upstream sequences and oriP
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DOI：
10.1128/jvi.75.13.6235-6241.2001
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发表时间：
2001-07-01
影响因子：
5.4
通讯作者：
Farrell, PJ
中科院分区：
文献类型：
--
作者：
Wensing, B;Stühler, A;Farrell, PJ
潜伏感染细胞中的大部分Epstein-Barr病毒基因组处于标准的核小体结构中，但包含ORip和Epstein-Barr病毒编码的小RNA(EBER)基因的区域在微球菌核酸酶消化时显示出独特的模式。这种模式对应于先前映射的核基质附着区。虽然EBER基因与ORIP相邻，但ORIP对EBER的表达只有两到四倍的影响。然而，包含EBER1上游共同ATF位点的序列对于EBER1的表达是重要的。
Most of the Epstein-Barr virus genome in latently infected cells is in a standard nucleosomal structure, but the region encompassing oriP and the Epstein-Barr virus-encoded small RNA (EBER) genes shows a distinctive pattern when digested with micrococcal nuclease. This pattern corresponds to a previously mapped nuclear matrix attachment region. Although the EBER genes are adjacent to oriP, there is only a two- to fourfold effect of oriP on EBER expression. However, sequences containing a consensus ATF site upstream of EBER1 are important for EBER1 expression.