Endothelial NOS G894T and MMP-3 5A/6A gene polymorphisms and hypertension in Serbian population
Endothelial NOS G894T and MMP-3 5A/6A gene polymorphisms and hypertension in Serbian population
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DOI：
10.1002/jcla.20085
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发表时间：
2005-01-01
影响因子：
2.7
通讯作者：
Alavantic, D
中科院分区：
文献类型：
--
作者：
Djuric, T;Zivkovic, M;Alavantic, D
高血压的发病率正在增加，并且男性比女性更常见。迄今为止，MMP-3 5A/6A 多态性与动脉硬化和血压升高有关，而考虑内皮型一氧化氮合酶 (eNOS) G894T 多态性与高血压的关联的结果存在争议。我们研究的目的是分析塞尔维亚人群中 eNOS G894T 和 MMP-3 5A/6A 基因多态性与高血压的可能关联。研究样本由 172 名高血压受试者和 200 名正常血压受试者组成，按性别划分。女性组和男性组均根据年龄进行截断。所有受试者均进行了 MMP-3 5A/6A 和 eNOS G894T 多态性基因分型。根据其隐性效应，显着较高（P = 50 岁）。在年轻男性中（
The incidence of hypertension is increasing and it is more common in man than in women. Up to date, MMP-3 5A/6A polymorphism has been associated with artery stiffening and elevated blood pressure, whereas results considering association of endothelial NOS (eNOS) G894T polymorphism with hypertension are controversial. The aim of our study was to analyze the possible association of eNOS G894T and MMP-3 5A/6A gene polymorphisms with hypertension in Serbian population. Study sample consisted of 172 hypertensive and 200 normotensive subjects divided by gender. Both female and male group was truncated according to age. All subjects were genotyped for MMP-3 5A/6A and eNOS G894T polymorphism. There was a significantly higher (P= 50 years, according to its recessive effect. In young males (