Microencapsulation by coacervation of poly(lactide‐co‐glycolide)—II: Encapsulation of a dispersed aqueous phase
Microencapsulation by coacervation of poly(lactide‐co‐glycolide)—II: Encapsulation of a dispersed aqueous phase
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通过聚（丙交酯-乙交酯）凝聚微胶囊化-II：分散水相的胶囊化
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
P. Teyssie
中科院分区：
文献类型：
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作者：
N. Nihant;S. Stassen;C. Grandfils;R. Jerome;P. Teyssie
本文研究了硅油对丙交酯和乙交酯共聚酯溶液相分离的影响，以促进蛋白质微胶囊化。该包衣过程可分为三个连续步骤：包衣聚合物的相分离;药物相周围凝聚液滴的吸附和微胶囊固化。本文重点介绍了第二步的理化分析。三个液相之间的界面张力的知识允许相分离介质的微观演变的理解。
This paper is related to the phase separation of different copolyesters of lactides and glycolide solutions induced by the addition of silicone oil in order to promote microencapsulation of proteins. This coating process can be divided in three successive steps: phase separation of the coating polymer; adsorption of the coacervate droplets around the drug phase, and microcapsule solidification. This paper focuses on the physico-chemical analysis of the second step. The knowledge of the interfacial tensions between the three liquid phases allows understanding of the microscopic evolution of the phase separation medium.